Increased MASH-associated liver cancer in younger demographics.

IF 5.6 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Communications Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI:10.1097/HC9.0000000000000629

Pojsakorn Danpanichkul, Yanfang Pang, Kanokphong Suparan, Thanida Auttapracha, Supapitch Sirimangklanurak, Abdelrahman M Attia, Chanattha Thimphitthaya, Michelle Shi Ni Law, Zhenning Yu, Mostafa A Soliman, Natchaya Polpichai, Chanakarn Kanitthamniyom, Donghee Kim, Mazen Noureddin, Amit G Singal, Karn Wijarnpreecha, Ju Dong Yang

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引用次数: 0

Abstract

Background: The incidence of cancer and the prevalence of metabolic disease and metabolic dysfunction-associated steatotic liver disease is increasing in young adults. However, updated global data on metabolic dysfunction-associated steatohepatitis (MASH)-associated primary liver cancer (PLC) in young adults remains scarce.

Methods: This study analyzed data from the Global Burden of Disease study between 2000 and 2021 to assess the age-standardized incidence, mortality, and disability-adjusted life years rates from MASH-associated PLC in young adults (15-49 y).

Results: In 2021, there were 4300 incidence cases, 3550 deaths, and 179,340 disability-adjusted life years from MASH-associated PLC in young adults. Among various etiologies of PLC in young adults, only MASH-associated PLC had increased incidence rates (annual percent change: +0.26, 95% CI: 0.16%-0.35%), with the Eastern Mediterranean region having the largest observed increase (annual percent change: 1.46%, 95% CI: 1.40%-1.51%). In 2021, MASH-associated PLC in young adults made up 6% (+1% from 2000) incident cases, 6% (+2% from 2000) deaths, and 6% (+2% from 2000) disability-adjusted life years of all PLC in this age group. Over half of the countries exhibited an increase in age-standardized incidence rate from MASH-associated PLC in young adults from 2000 to 2021.

Conclusions: The incidence of MASH-associated PLC in young adults is significantly increasing, signaling likely future increases in PLC incidence among older adults as this cohort ages. This trend necessitates urgent strategies worldwide to mitigate the epidemics of MASH-associated PLC in young adults.

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mash相关肝癌在年轻人群中增加。

背景：在年轻人中，癌症的发病率和代谢性疾病和代谢功能障碍相关的脂肪变性肝病的患病率正在增加。然而，关于年轻人代谢功能障碍相关脂肪性肝炎（MASH）相关原发性肝癌（PLC）的最新全球数据仍然很少。方法：本研究分析了2000年至2021年全球疾病负担研究的数据，以评估年轻人（15-49岁）mash相关PLC的年龄标准化发病率、死亡率和残疾调整生命年率。结果：2021年，年轻人mash相关PLC有4300例发病率，3550例死亡，179340例残疾调整生命年。在年轻人PLC的各种病因中，只有msh相关的PLC发病率增加（年变化百分比：+0.26,95% CI: 0.16%-0.35%），东地中海地区的发病率增幅最大（年变化百分比：1.46%,95% CI: 1.40%-1.51%）。2021年，年轻人中与mash相关的PLC占该年龄组所有PLC的6%（比2000年增加1%）事件病例、6%（比2000年增加2%）死亡和6%（比2000年增加2%）残疾调整生命年。从2000年到2021年，超过一半的国家显示年轻人中与mash相关的PLC的年龄标准化发病率增加。结论：年轻人中mash相关PLC的发病率正在显著增加，这表明随着该队列年龄的增长，老年人中PLC的发病率可能会增加。这一趋势需要在世界范围内采取紧急战略，以减轻与mash相关的PLC在年轻人中的流行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Communications GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

8.00

自引率

2.00%

发文量

248

审稿时长

8 weeks

期刊介绍： Hepatology Communications is a peer-reviewed, online-only, open access journal for fast dissemination of high quality basic, translational, and clinical research in hepatology. Hepatology Communications maintains high standard and rigorous peer review. Because of its open access nature, authors retain the copyright to their works, all articles are immediately available and free to read and share, and it is fully compliant with funder and institutional mandates. The journal is committed to fast publication and author satisfaction.