The Role of Lifestyle and Environmental Factors in the Pathogenesis of Multiple Myeloma.

IF 2.3 3区医学 Q2 HEMATOLOGY

European Journal of Haematology Pub Date : 2025-01-08 DOI:10.1111/ejh.14356

Anna Suska, Agata Tyczyńska, Jan Maciej Zaucha, Anna Kopińska, Grzegorz Helbig, Mirosław Markiewicz, Katarzyna Warzybok, Ewa Leder, Sebastian Grosicki, Bogusław Machaliński, Bartłomiej Baumert, Michał Bator, Lidia Usnarska-Zubkiewicz, Szymon Fornagiel, Hanna Ciepłuch, Anna Waszczuk-Gajda, Kamila Kruczkowska-Tarantowicz, Piotr Rzepecki, Marek Hus, Anna Morawska-Krekora, Małgorzata Raźny, Grzegorz Charliński, Anna Puła, Ewa Nita, Małgorzata Wojciechowska, Małgorzata Krawczyk-Kuliś, Joanna Goldberg, Tomasz Woźny, Marek Rodzaj, Dariusz Olejarz, Marlena Gronau-Dziurkowska, Ewa Skalniak, Janusz Krzysztoń, Karolina Niezabitowska, Artur Jurczyszyn

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引用次数: 0

Abstract

Objectives: The study evaluated the impact of lifestyle and environmental exposure on the etiology of multiple myeloma (MM).

Methods: A multicenter case-control study was conducted in 20 hematology centers and in 5 outpatient clinics in Poland. The questionnaire on exposure to potential risk factors including sociodemographic data, lifestyle, and environmental factors was completed.

Results: A total of 274 patients with newly diagnosed MM and 208 patients from primary healthcare centers in the control group were enrolled in the study. Regarding lifestyle, sports practiced systematically for at least half a year play a protective role in the development of myeloma (OR = 0.40, 95% CI, 0.28-0.58, p < 0.001). Among environmental factors harmful exposures that increase the likelihood of the development of MM include pesticides (OR = 3.29, p < 0.001), asphalt (OR = 2.42, p = 0.026), coal dust (OR = 2.27, p = 0.004), organic vapors (OR = 2.11, p = 0.001), metal dust (OR = 2.07, p = 0.023), exhaust fumes (OR = 2.03, p < 0.01), and chemicals (OR = 1.80, p < 0.01).

Conclusions: The pathogenesis of MM is complex with the impact of modifiable factors. Lifestyle, with physical activity, seems to play a key role.

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生活方式和环境因素在多发性骨髓瘤发病中的作用。

目的：本研究评估生活方式和环境暴露对多发性骨髓瘤（MM）病因的影响。方法：在波兰20个血液学中心和5个门诊进行了一项多中心病例对照研究。完成潜在危险因素暴露问卷，包括社会人口统计数据、生活方式和环境因素。结果：共有274例新诊断的MM患者和208例来自初级卫生保健中心的患者被纳入研究。生活方式方面，系统锻炼半年以上的运动对骨髓瘤的发生有保护作用（OR = 0.40, 95% CI, 0.28-0.58, p）。结论：骨髓瘤的发病机制复杂，可调节因素的影响。生活方式和身体活动似乎起着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Haematology 医学-血液学

CiteScore

5.50

自引率

0.00%

发文量

168

审稿时长

4-8 weeks

期刊介绍： European Journal of Haematology is an international journal for communication of basic and clinical research in haematology. The journal welcomes manuscripts on molecular, cellular and clinical research on diseases of the blood, vascular and lymphatic tissue, and on basic molecular and cellular research related to normal development and function of the blood, vascular and lymphatic tissue. The journal also welcomes reviews on clinical haematology and basic research, case reports, and clinical pictures.