Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2025-01-08 DOI:10.2174/0113894501354898241220075327

Sejal Porwal, Rishabha Malviya, Sonali Sundram, Sathvik Belagodu Sridhar, Javedh Shareef

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引用次数: 0

Abstract

Managing diabetic wounds is a significant challenge for healthcare professionals since severe complications and delayed recovery greatly impact the patients' quality of life. This article aimed to explore various factors affecting diabetic wound healing, the mechanism of wound healing, and potential natural products having wound healing capability. It focuses on mechanisms of action and the therapeutic effectiveness of the compounds employed in the management of diabetic wounds. The review discusses the function of nutrition in wound healing, emphasizing the significance of consuming adequate amounts of protein, energy, lipids, amino acids, vitamins, minerals, and water to promote healing. Several herbs, including Rosmarinus officinalis, Carica papaya, Aloe vera, Annona squamosa, and Punica granatum, are being tested for wound healing qualities in diabetes circumstances. These plants have a variety of modes of action, including antioxidant, anti-inflammatory, antibacterial, and immunomodulatory activities that help to speed up wound healing, stimulate collagen formation, and promote tissue regeneration. The variety of action mechanisms seen in natural products, especially in plants, offers hope for the treatment of diabetic wounds. It may also be possible to improve healing results and the quality of life of diabetes individuals with chronic wounds by including these herbal treatments in wound care programs.

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糖尿病伤口愈合：使用草药成分的因素、机制和治疗策略。

糖尿病伤口的处理是医护人员面临的一个重大挑战，因为严重的并发症和延迟恢复极大地影响了患者的生活质量。本文旨在探讨影响糖尿病创面愈合的各种因素、创面愈合的机制以及潜在的具有创面愈合能力的天然产物。它的重点是作用机制和治疗效果的化合物用于糖尿病伤口的管理。本文讨论了营养在伤口愈合中的作用，强调了摄入足量的蛋白质、能量、脂质、氨基酸、维生素、矿物质和水对促进伤口愈合的重要性。几种草药，包括迷迭香、番木瓜、芦荟、番荔枝和石榴，正在对糖尿病患者的伤口愈合质量进行测试。这些植物具有多种作用模式，包括抗氧化、抗炎、抗菌和免疫调节活性，有助于加速伤口愈合、刺激胶原蛋白形成和促进组织再生。在天然产物中，特别是在植物中看到的各种作用机制，为糖尿病伤口的治疗提供了希望。通过将这些草药治疗纳入伤口护理计划，也可能改善慢性伤口的糖尿病患者的愈合效果和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.