Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers.

IF 3.8 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2025-01-07 DOI:10.2174/0115665232338503241227111640

Atabak Naiyeri, Amin Moqadami, Mohammad Khalaj-Kondori

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引用次数: 0

Abstract

Dementia is a comprehensive term that refers to illnesses characterized by a decline in cognitive memory and other cognitive functions, affecting a person's overall ability to operate. The exact causes of dementia are unknown to this day. The heterogeneity of Alzheimer's indicates the contribution of genetic polymorphism to this disease. This disease is the most prevalent and damaging illness. Studies indicate that the global prevalence of Alzheimer's disease (AD) exceeds 26 million individuals. Investigation of variations in many genes indicates that these variations may be linked to the susceptibility to AD. Additional genetic factors could potentially influence AD. Analysis of several single-nucleotide polymorphisms in this context reveals a correlation between certain variants and AD. Regardless, Alzheimer's disease is always influenced by a particular APOE gene allele. The study's findings indicate that risk of Alzheimer's disease (AD) is linked to polymorphisms in the following genes: BDNF, presenilin-1 (PS-1), presenilin-2 (PS-2), LRP, APP, CTSD,5-6HT, TREM2, TNF-α, LPL, Clusterin (CLU), SORL1 (Sortilin-Related Receptor), PICALM, Complement Receptor 1 (CR1), and APOE genes.

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解开阿尔茨海默氏症的遗传线索：洞察风险因素和生物标志物。

痴呆症是一个综合性术语，指的是以认知记忆和其他认知功能下降为特征的疾病，影响了一个人的整体操作能力。痴呆的确切病因至今仍不清楚。阿尔茨海默病的异质性表明遗传多态性对这种疾病的贡献。这种疾病是最普遍和最具破坏性的疾病。研究表明，阿尔茨海默病（AD）的全球患病率超过2600万人。对许多基因变异的研究表明，这些变异可能与阿尔茨海默病的易感性有关。其他遗传因素也可能影响阿尔茨海默病。在这种情况下，对几个单核苷酸多态性的分析揭示了某些变异与AD之间的相关性。无论如何，阿尔茨海默病总是受到特定的APOE基因等位基因的影响。研究结果表明，阿尔茨海默病（AD）的风险与以下基因的多态性有关：BDNF、早老素-1 （PS-1）、早老素-2 （PS-2）、LRP、APP、CTSD、5-6HT、TREM2、TNF-α、LPL、Clusterin （CLU）、SORL1 （sortilin相关受体）、PICALM、补体受体1 （CR1）和APOE基因。

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.