Integrated proteogenomic characterization of ampullary adenocarcinoma.

IF 13 1区生物学 Q1 CELL BIOLOGY

Cell Discovery Pub Date : 2025-01-07 DOI:10.1038/s41421-024-00742-4

Qiao Zhang, Xiaomeng Xu, Dongxian Jiang, Yunzhi Wang, Haixing Wang, Jiajun Zhu, Shaoshuai Tang, Ronghua Wang, Shuang Zhao, Kai Li, Jinwen Feng, Hang Xiang, Zhenmei Yao, Ning Xu, Rundong Fang, Wenjia Guo, Yu Liu, Yingyong Hou, Chen Ding

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Abstract

Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples from Chinese AMPAC patients and duodenum patients. Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation. Proteomic analysis has revealed three distinct clusters (C-FAM, C-AD, C-CC), among which the most aggressive cluster, C-AD, is associated with the poorest prognosis and is characterized by focal adhesion. Immune clustering identifies three immune clusters and reveals that immune cluster M1 (macrophage infiltration cluster) and M3 (DC cell infiltration cluster), which exhibit a higher immune score compared to cluster M2 (CD4⁺ T-cell infiltration cluster), are associated with a poor prognosis due to the potential secretion of IL-6 by tumor cells and its consequential influence. This study provides a comprehensive proteogenomic analysis for seeking for better understanding and potential treatment of AMPAC.

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壶腹腺癌的综合蛋白质基因组学特征。

壶腹腺癌（AMPAC）是一种罕见的异质性恶性肿瘤。在这里，我们对来自中国AMPAC患者和十二指肠患者的198个样本进行了全面的蛋白质基因组学分析。基因组数据表明，4q缺失导致脂肪酸积累和细胞增殖。蛋白质组学分析揭示了三种不同的簇（C-FAM, C-AD, C-CC），其中最具侵袭性的簇C-AD与预后最差相关，其特征为局灶粘连。免疫聚类鉴定出三个免疫簇，发现免疫簇M1（巨噬细胞浸润簇）和M3 （DC细胞浸润簇）的免疫评分高于簇M2 （CD4+ t细胞浸润簇），由于肿瘤细胞可能分泌IL-6及其影响，导致预后不良。本研究提供了全面的蛋白质基因组学分析，以寻求更好的理解和潜在的治疗AMPAC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Discovery Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

24.20

自引率

0.60%

发文量

120

审稿时长

20 weeks

期刊介绍： Cell Discovery is a cutting-edge, open access journal published by Springer Nature in collaboration with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). Our aim is to provide a dynamic and accessible platform for scientists to showcase their exceptional original research. Cell Discovery covers a wide range of topics within the fields of molecular and cell biology. We eagerly publish results of great significance and that are of broad interest to the scientific community. With an international authorship and a focus on basic life sciences, our journal is a valued member of Springer Nature's prestigious Molecular Cell Biology journals. In summary, Cell Discovery offers a fresh approach to scholarly publishing, enabling scientists from around the world to share their exceptional findings in molecular and cell biology.