Evaluation of dose calculation method with a combination of Monte Carlo method and removal-diffusion equation in heterogeneous geometry for boron neutron capture therapy.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Biomedical Physics & Engineering Express Pub Date : 2025-01-09 DOI:10.1088/2057-1976/ada7fe

Mai Nojiri, Takushi Takata, Akinori Sasaki, Yuki Tamari, Nishiki Matsubayashi, Naonori Hu, Yoshinori Sakurai, Minoru Suzuki, Hiroki Tanaka

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引用次数: 0

Abstract

Clinical research in boron neutron capture therapy (BNCT) has been conducted worldwide. Currently, the Monte Carlo (MC) method is the only dose calculation algorithm implemented in the treatment planning system for the clinical treatment of BNCT. We previously developed the MC-RD calculation method, which combines the MC method and the removal-diffusion (RD) equation, for fast dose calculation in BNCT. This study aimed to verify the partial-MC-RD calculation method, which utilizes the MC-RD calculation method for a portion of the entire neutron energy range, in terms of calculation accuracy and time as the dose calculation method. We applied the partial-MC-RD calculation method to calculate the total dose for head phantom, comprising soft tissue, brain tissue, and bone. The calculation time and accuracy were evaluated based on the full-MC method. Our accuracy verifications indicated that the partial-MC-RD calculation was mostly comparable with full-MC calculation in the accuracy. However, the assumptions and approximation used in the RD calculation mainly occurred the discrepancy from the full-MC calculation result. Additionally, the partial-MC-RD calculation reduced the time required to approximately 45% for the irradiation to the top and cheek region of head phantom, compared to the full-MC calculation. In conclusion, the MC-RD calculation method can be the basis of a fast dose calculation method in BNCT.

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来源期刊

Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.80

自引率

0.00%

发文量

153

期刊介绍： BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.