{"title":"Heavy Metals Alter the Anti-cancer Potency of Medicinal Plants.","authors":"Amber Rizwan, Aatiquah Aqeel, Aisha Idris, Humaira Farooqi","doi":"10.2174/0118715206341220241120132600","DOIUrl":null,"url":null,"abstract":"<p><p>This review investigates the outcome of heavy metal contamination on the anti-cancer properties of medicinal plants. Heavy metal pollution is a significant environmental concern globally, often found in soil and water due to industrial activities. Therapeutic plants are recognized because of their therapeutic attributes and their ability to absorbing these contaminants. This study examines how heavy metal exposure modifies the chemical composition and efficacy of medicinal plants against cancer cells. Through a comprehensive review of existing literature and experimental analysis, we explore the mechanisms by which heavy metals interact with bioactive compounds in medicinal plants, affecting their anti-cancer potency. Findings reveal intricate interactions among heavy metals and phytochemicals, leading to variations in cytotoxicity against cancer cells. Comprehending these interactions is crucial for optimizing the utilization of medicinal plants in cancer treatment and for developing approaches to alleviate the impacts of heavy metal contamination on their therapeutic potential. The urgency of this issue cannot be overstated, as it directly impacts our ability to effectively treat cancer and preserve our environment.</p>","PeriodicalId":7934,"journal":{"name":"Anti-cancer agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anti-cancer agents in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0118715206341220241120132600","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
This review investigates the outcome of heavy metal contamination on the anti-cancer properties of medicinal plants. Heavy metal pollution is a significant environmental concern globally, often found in soil and water due to industrial activities. Therapeutic plants are recognized because of their therapeutic attributes and their ability to absorbing these contaminants. This study examines how heavy metal exposure modifies the chemical composition and efficacy of medicinal plants against cancer cells. Through a comprehensive review of existing literature and experimental analysis, we explore the mechanisms by which heavy metals interact with bioactive compounds in medicinal plants, affecting their anti-cancer potency. Findings reveal intricate interactions among heavy metals and phytochemicals, leading to variations in cytotoxicity against cancer cells. Comprehending these interactions is crucial for optimizing the utilization of medicinal plants in cancer treatment and for developing approaches to alleviate the impacts of heavy metal contamination on their therapeutic potential. The urgency of this issue cannot be overstated, as it directly impacts our ability to effectively treat cancer and preserve our environment.
期刊介绍:
Formerly: Current Medicinal Chemistry - Anti-Cancer Agents.
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.
Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.