The landscape of GPCR in the skin epidermal stem cells: From the basic to the clinical.

Q3 Medicine
生理学报 Pub Date : 2024-12-25
Zhi-Lin Zhang, Xiao-Qing Ma, Zhao-Tian Zhang, Rong-Hao Zhang, Ru-Tao Cui
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引用次数: 0

Abstract

Skin, as the body's largest organ, acts as the primary defense mechanism against infection and injury. The maintenance of skin health heavily relies on the regulation of epidermal stem cells, crucial for ensuring epidermal homeostasis, hair regeneration, and the repair of epidermal injuries. Recent studies have placed a growing emphasis on G protein-coupled receptor (GPCR) in the context of understanding epidermal stem cells, uncovering its significant role in determining their fate. The activation of GPCR triggers the subsequent dissociation of the βγ subunits from the α subunit of G protein, leading to the modulation of various downstream signaling pathways, such as the WNT-BMP signaling crosstalk and the Gαs-PKA signaling pathway. These pathways collectively influence the fate of epidermal stem cells. Consequently, targeted GPCR therapy has emerged as a promising strategy for improving skin health by orchestrating the fate of epidermal stem cells, unveiling potential therapeutic targets that demand further investigation.

GPCR在皮肤表皮干细胞中的应用前景:从基础到临床。
皮肤作为人体最大的器官,是抵御感染和损伤的主要防御机制。皮肤健康的维持在很大程度上依赖于表皮干细胞的调节,它对确保表皮稳态、毛发再生和表皮损伤的修复至关重要。最近的研究越来越强调G蛋白偶联受体(GPCR)在理解表皮干细胞的背景下,揭示其在决定其命运中的重要作用。GPCR的激活触发G蛋白βγ亚基与α亚基的解离,导致多种下游信号通路的调节,如WNT-BMP信号串扰和Gαs- pka信号通路。这些途径共同影响表皮干细胞的命运。因此,靶向GPCR治疗已成为一种有希望的策略,通过协调表皮干细胞的命运来改善皮肤健康,揭示了需要进一步研究的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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