Excited Pd-catalyzed dearomative 1,4-dicarbofunctionalization of nonactivated aromatic rings

Abstract

Excited-palladium catalysis has already been exploited to achieve 1,4-difunctionalization of dienes via the radical generation of allylpalladium intermediate. Herein, the nonactivated phenyl rings that are treated as the masked trienes, have accomplished dearomative 1,4-dicarbofunctionalization in the excited-palladium catalytic two- and three-component system. A wide range of alkyl bromides, and 1,3-dicarbonyl compounds, which play the roles of radical precursor and nucleophile respectively, were found to be suitable for this reaction. Various three-dimensional molecular architecture with multiple quaternary carbon centers were efficiently constructed through this mild reaction.