Condition-Controlled Rh(III)-Catalyzed Chemodivergent Cyclization of 2-Arylpyridines with CF3-Imidoyl Sulfoxonium Ylides via Triple C–H Activation

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-07 DOI:10.1021/acs.orglett.4c04514

Xiaoyang Gao, Ruirui Zhai, Juting Liao, Guiwei Yao, Hui Meng, Yuchao Luo, Dulin Kong, Shuojin Wang, Xun Chen

引用次数: 0

Abstract

A condition-controlled Rh(III)-catalyzed selective synthesis of CF₃-substituted indoles and pyrido[2,1-a]isoindoles from 2-arylpyridines and CF₃-imidoyl sulfoxonium ylides has been developed. The Cp*Rh(MeCN)₃(SbF₆)₂/HFIP system afforded CF₃-substituted indoles via triple C–H activation, while the [Cp*RhCl₂]₂/MeCN condition selectively furnished CF₃-substituted pyrido[2,1-a]isoindoles through C–H [4 + 1] annulation. The notable advantages of this developed method included readily available starting materials, broad substrate scope, and excellent chemoselectivity. Importantly, several selected products showed promising antitumor activities.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.