Extracellular vimentin amplifies inflammation: Perspectives for immune injury and therapeutics for periodontitis

IF 4.4 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhiyao Yuan, Patricio Smith, Christopher A. McCulloch
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引用次数: 0

Abstract

Periodontitis is an inflammatory disease triggered by microbial biofilms that promote immune dysfunction and tissue destruction of tooth-supporting tissues. The search for soluble mediators that amplify inflammatory responses and matrix degradation in periodontal tissues has implicated extracellular vimentin (ECV) as a signaling ligand and damage-associated molecular pattern in the pathogenesis of periodontitis. Intracellular vimentin filaments are essential for the structural integrity of cells and the preservation of matrix homeostasis. These are important determinants of health in the periodontium and many other organs. But in inflamed tissues, intracellular vimentin filaments are disassembled. Vimentin is subsequently released from cells into the extracellular space in a soluble form where it drives immune signaling and tissue destruction. We discuss the role of ECV as a signaling molecule in several tissues. We apply these data to understand how in inflammatory diseases like periodontitis, ECV amplifies immune responses that contribute to disease progression. Arising from these data, we consider novel therapeutic opportunities for limiting tissue destruction by targeting ECV for treatment of inflammatory disorders like periodontitis.

Abstract Image

细胞外波形蛋白放大炎症:对牙周炎的免疫损伤和治疗的看法。
牙周炎是一种由微生物生物膜引发的炎症性疾病,微生物生物膜促进免疫功能障碍和牙齿支持组织的组织破坏。对可增强牙周组织炎症反应和基质降解的可溶性介质的研究表明,细胞外波形蛋白(ECV)在牙周炎的发病机制中是一种信号配体和损伤相关的分子模式。细胞内的静脉蛋白丝对于细胞的结构完整性和维持基质稳态至关重要。这些是牙周组织和许多其他器官健康的重要决定因素。但在炎症组织中,细胞内的静脉蛋白细丝被分解。随后,Vimentin以可溶性形式从细胞释放到细胞外空间,在那里它驱动免疫信号和组织破坏。我们讨论了ECV作为信号分子在几种组织中的作用。我们应用这些数据来了解在像牙周炎这样的炎症性疾病中,ECV如何放大导致疾病进展的免疫反应。基于这些数据,我们考虑通过靶向ECV治疗炎症性疾病(如牙周炎)来限制组织破坏的新治疗机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
The FASEB Journal
The FASEB Journal 生物-生化与分子生物学
CiteScore
9.20
自引率
2.10%
发文量
6243
审稿时长
3 months
期刊介绍: The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.
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