[Clinical efficacy of sublingual immunotherapy for allergic rhinitis].

Syuji Yonekura
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Abstract

The prevalence of allergic rhinitis (AR) reached 49.2% in 2019. In particular, the prevalence of Japanese cedar (JC) pollinosis is 38.8%, and the onset age of pollinosis is becoming younger. AR is known to be a risk factor for the development of allergic asthma, a potentially life-threatening condition. Allergen immunotherapy (AIT) is a well-documented, safe, effective treatment option for respiratory allergic disease. It has been demonstrated that AIT can provide relief from clinical symptoms and that AIT has the potential to provide long-term post-treatment effect. Unlike pharmacotherapy, AIT addresses the basic immunological mechanisms that are responsible for the development and persistence of allergic conditions. Currently, two main routes of AIT administration, subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT), are commonly available. In Japan, house dust mite (HDM) SLIT tablets have been available since 2015, and JC SLIT tablet had been approved by 2018 without any age limitation. The randomized double-blind, placebo-controlled trials that included pediatric patients have been conducted in Japan. In phase II/III trail with JC SLIT tablets, treatment effect-size (improvement of clinical symptoms compared to placebo) was 46.3% after three years treatment. In addition, AR was improved in 40% (1 year) and 30% (2 years) after discontinuation of SLIT. Several future initiatives including the AIT against cedar pollen allergies were announced by Japanese government. This review covered the findings to date, including immunotherapy not only for JC pollinosis- but also for HDM-induced perennial AR.

舌下免疫治疗变应性鼻炎的临床疗效观察
2019年过敏性鼻炎(AR)患病率达到49.2%。其中杉木(JC)花粉症患病率为38.8%,发病年龄呈低龄化趋势。已知过敏性哮喘是过敏性哮喘发展的一个危险因素,过敏性哮喘是一种潜在的危及生命的疾病。过敏原免疫疗法(AIT)是一种记录良好、安全、有效的治疗呼吸道过敏性疾病的选择。经证实,体外循环治疗可以缓解临床症状,并有可能提供长期的治疗后效果。与药物治疗不同,AIT解决了导致过敏状况发展和持续的基本免疫机制。目前,两种主要的AIT给药途径是皮下免疫治疗(SCIT)和舌下免疫治疗(SLIT)。在日本,屋尘螨(HDM) SLIT片剂自2015年起上市,JC SLIT片剂于2018年获得批准,没有任何年龄限制。在日本进行了随机双盲、安慰剂对照试验,其中包括儿科患者。在JC SLIT片的II/III期临床试验中,治疗效果(与安慰剂相比,临床症状的改善)在治疗3年后为46.3%。此外,停止SLIT后,40%(1年)和30%(2年)的AR得到改善。日本政府宣布了几项未来的倡议,包括针对雪松花粉过敏的美国在台协会。这篇综述涵盖了迄今为止的发现,包括免疫治疗不仅对JC花粉症,而且对hdm诱导的多年生AR。
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来源期刊
Folia Pharmacologica Japonica
Folia Pharmacologica Japonica Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
132
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