Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects.

IF 2.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Hesti Lina Wiraswati, Ilma Fauziah Ma'ruf, Nur Akmalia Hidayati, Julia Ramadhanti, Daniela Calina, Javad Sharifi-Rad
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Abstract

Cancer therapy continues to face critical challenges, including drug resistance, recurrence, and severe side effects, which often compromise patient outcomes and quality of life. Exploring novel, cost-effective approaches, this review highlights the potential of Piper nigrum (black pepper) extract (PNE) as a complementary anticancer agent. Piper nigrum, a widely available spice with a rich history in traditional medicine, contains bioactive compounds such as piperine, which have demonstrated significant anticancer activities including cell cycle arrest, apoptosis induction, and inhibition of tumor growth and metastasis. The review evaluates the recent findings from in vitro, in vivo, and clinical studies, emphasizing PNE's capacity to enhance the efficacy of conventional chemotherapeutic agents while mitigating their side effects. Key mechanisms underlying these effects include oxidative stress modulation, suppression of pro-metastatic factors, and synergistic interactions with established drugs like doxorubicin and paclitaxel. These interactions suggest that PNE could play a pivotal role in overcoming chemoresistance and improving therapeutic outcomes. Furthermore, this review highlights the potential benefits of PNE in resource-limited settings, where the cost of cancer treatments often restricts access. However, challenges such as compositional variability, limited bioavailability, and the need for standardization and clinical validation need to be addressed to advance the integration of PNE into basic oncology. By providing a comprehensive analysis of the anticancer mechanisms of PNE and its potential as a cost-effective adjuvant therapy, this review provides new insight into the exploitation of Piper nigrum to improve cancer treatment efficacy while reducing side effects. Future research directions are discussed to address current limitations and facilitate clinical translation.

利用胡椒的抗癌潜力:一种增强化疗和减少副作用的协同方法。
癌症治疗仍然面临着严峻的挑战,包括耐药性、复发和严重的副作用,这些往往会影响患者的预后和生活质量。探索新颖,经济有效的方法,这篇综述强调了胡椒(黑胡椒)提取物(PNE)作为一种补充抗癌剂的潜力。胡椒是一种广泛使用的香料,在传统医学中有着悠久的历史,它含有胡椒碱等生物活性化合物,具有显著的抗癌活性,包括细胞周期阻滞、诱导细胞凋亡和抑制肿瘤生长和转移。该综述评估了最近在体外、体内和临床研究中的发现,强调PNE能够增强传统化疗药物的疗效,同时减轻其副作用。这些作用的关键机制包括氧化应激调节、抑制促转移因子以及与阿霉素和紫杉醇等现有药物的协同相互作用。这些相互作用表明PNE可能在克服化疗耐药和改善治疗结果方面发挥关键作用。此外,本综述强调了PNE在资源有限的环境中的潜在益处,在这些环境中,癌症治疗的成本往往限制了获取。然而,为了推进PNE与基础肿瘤学的整合,需要解决诸如成分可变性、有限的生物利用度、标准化和临床验证的需求等挑战。通过对PNE的抗癌机制及其作为一种具有成本效益的辅助治疗的潜力的全面分析,本综述为利用红椒提高癌症治疗疗效并减少副作用提供了新的见解。讨论了未来的研究方向,以解决目前的局限性,促进临床翻译。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Discover. Oncology
Discover. Oncology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.40
自引率
9.10%
发文量
122
审稿时长
5 weeks
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