{"title":"A guide for asymmetric synthesis of morphine alkaloids","authors":"Hui Zhao, Yunfei Cheng","doi":"10.1007/s00044-024-03350-9","DOIUrl":null,"url":null,"abstract":"<div><p>A collection of structurally related natural compounds derived from Papaver somniferum, the opium poppy, are known as the morphine alkaloids. Many generations of synthetic chemists have been drawn to the synthesis of morphine and its derivatives owing to their extraordinarily complex molecular architecture and exceptional biological activity. This overview highlights recent advance in the asymmetric synthesis of morphine alkaloids, focusing on various strategies for introducing and controlling chirality, which will hasten the feasibility of commercial production of morphinan.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 2","pages":"319 - 339"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00044-024-03350-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
A collection of structurally related natural compounds derived from Papaver somniferum, the opium poppy, are known as the morphine alkaloids. Many generations of synthetic chemists have been drawn to the synthesis of morphine and its derivatives owing to their extraordinarily complex molecular architecture and exceptional biological activity. This overview highlights recent advance in the asymmetric synthesis of morphine alkaloids, focusing on various strategies for introducing and controlling chirality, which will hasten the feasibility of commercial production of morphinan.
期刊介绍:
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.