The cardio-metabolic protein profile is associated with development of type 2 diabetes at long term follow-up after gestational diabetes mellitus: Results from the OGFUS study

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2025-01-02 DOI:10.1111/dom.16148

Simone J. Hallig MD, Jori Aalders PhD, Maria H. Christensen PhD, Marianne S. Andersen PhD, Christina A. Vinter PhD, Fidelma Dunne PhD, Kurt Højlund PhD, Dorte M. Jensen PhD, Martin Overgaard PhD

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Abstract

Aims

Women with previous gestational diabetes mellitus (GDM) have an increased risk for later development of type 2 diabetes. During pregnancy, GDM affects the cardio-metabolic protein profile; however, it is unknown how GDM affects the cardio-metabolic protein profile in the long term and if it is associated with type 2 diabetes after GDM. We hypothesise that the cardio-metabolic protein profile is affected long term and is associated with the development of type 2 diabetes after GDM.

Materials and Methods

A case–control follow-up study based on the Odense GDM Follow-Up Study (OGFUS) cohort, which included women with previous GDM (n = 128) and matched controls without previous GDM (n = 70). Blood samples from a follow-up assessment 8–10 years after delivery were analysed using a 29-plex panel of apolipoproteins, transport and inflammation/immune proteins using multiple-reaction-monitoring mass spectrometry.

Results

Apolipoprotein A-I, D and M were significantly lower in women with previous GDM compared to controls (all p < 0.001), while apolipoprotein L-I, H, vitamin D binding protein, CRP, vitronectin, transthyretin and complement factors 3 and B were significantly higher (p = 0.008, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.005, respectively). All associations remained significant after adjustment for multiple testing except CRP, whereas apolipoprotein D, vitronectin and complement factors 3 and B were associated with the development of type 2 diabetes in women with previous GDM (p = 0.02, p = 0.001, p < 0.001, p = 0.004, respectively).

Conclusions

The cardio-metabolic protein profile 8–10 years after pregnancy is altered in women with previous GDM. Apolipoprotein D, vitronectin and complement factors 3 and B are candidate risk markers of type 2 diabetes after GDM pregnancy.

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OGFUS研究的结果表明，妊娠期糖尿病后长期随访的心脏代谢蛋白谱与2型糖尿病的发展有关。

目的：既往妊娠期糖尿病（GDM）的妇女后期发展为2型糖尿病的风险增加。妊娠期，GDM影响心脏代谢蛋白谱；然而，目前尚不清楚GDM如何长期影响心脏代谢蛋白谱，以及它是否与GDM后的2型糖尿病有关。我们假设心脏代谢蛋白谱受到长期影响，并与GDM后2型糖尿病的发展有关。材料和方法：一项基于欧登塞GDM随访研究（OGFUS）队列的病例对照随访研究，其中包括既往GDM的女性（n = 128）和匹配的对照组（n = 70）。分娩后8-10年随访评估的血液样本使用多重反应监测质谱分析29层载脂蛋白、转运蛋白和炎症/免疫蛋白。结果：与对照组相比，既往GDM妇女的载脂蛋白A-I、D和M显著降低（均为p）。结论：妊娠后8-10年，既往GDM妇女的心脏代谢蛋白谱发生改变。载脂蛋白D、玻璃体粘连蛋白和补体因子3和B是妊娠期GDM后2型糖尿病的候选危险标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.