Cytomegalovirus Infections in Patients Diagnosed with Inflammatory Bowel Disease.

Infectious diseases & clinical microbiology Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI:10.36519/idcm.2024.370
Melike İnan-Hekimoğlu, Elif Mukime Sarıcaoğlu, Güle Çınar, İrem Akdemir, Ezgi Gülten, Murat Törüner, Arzu Ensari, Berna Savaş, Kemal Osman Memikoğlu
{"title":"Cytomegalovirus Infections in Patients Diagnosed with Inflammatory Bowel Disease.","authors":"Melike İnan-Hekimoğlu, Elif Mukime Sarıcaoğlu, Güle Çınar, İrem Akdemir, Ezgi Gülten, Murat Törüner, Arzu Ensari, Berna Savaş, Kemal Osman Memikoğlu","doi":"10.36519/idcm.2024.370","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The impact of cytomegalovirus (CMV) on inflammatory bowel disease (IBD) flares remains a matter of debate. This study aimed to evaluate patients with CMV infection who presented with IBD exacerbation in terms of diagnosis and treatment and investigate the importance of CMV DNA levels in colitis development.</p><p><strong>Materials and methods: </strong>Patients who were followed up with IBD and examined with clinical suspicion of CMV colitis at a university hospital between January 2016 and December 2021 were retrospectively scanned. This study included all patients who underwent colonoscopic biopsy with a preliminary diagnosis of CMV colitis and compared those with colitis detected histopathologically with those without colitis.</p><p><strong>Results: </strong>Thirty-nine patients with IBD were included in the study. No statistically significant difference was observed regarding the two groups' demographic data, clinical findings, and outcomes. The median serum CMV DNA level in patients with CMV colitis was 104 copies/mL, which was lower than in patients without colitis (1216 copies/mL) (<i>p</i>=0.008). Among patients with CMV colitis, CMV DNA levels were negative or low in 16 (61.5%).</p><p><strong>Conclusion: </strong>In patients with IBD, CMV colitis may not always be accompanied by CMV viremia. Therefore, negative or low serum CMV DNA levels are not sufficient to exclude CMV colitis. In case of high clinical suspicion, further examinations should be planned.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"6 4","pages":"282-290"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687240/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases & clinical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36519/idcm.2024.370","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: The impact of cytomegalovirus (CMV) on inflammatory bowel disease (IBD) flares remains a matter of debate. This study aimed to evaluate patients with CMV infection who presented with IBD exacerbation in terms of diagnosis and treatment and investigate the importance of CMV DNA levels in colitis development.

Materials and methods: Patients who were followed up with IBD and examined with clinical suspicion of CMV colitis at a university hospital between January 2016 and December 2021 were retrospectively scanned. This study included all patients who underwent colonoscopic biopsy with a preliminary diagnosis of CMV colitis and compared those with colitis detected histopathologically with those without colitis.

Results: Thirty-nine patients with IBD were included in the study. No statistically significant difference was observed regarding the two groups' demographic data, clinical findings, and outcomes. The median serum CMV DNA level in patients with CMV colitis was 104 copies/mL, which was lower than in patients without colitis (1216 copies/mL) (p=0.008). Among patients with CMV colitis, CMV DNA levels were negative or low in 16 (61.5%).

Conclusion: In patients with IBD, CMV colitis may not always be accompanied by CMV viremia. Therefore, negative or low serum CMV DNA levels are not sufficient to exclude CMV colitis. In case of high clinical suspicion, further examinations should be planned.

确诊为炎症性肠病患者的巨细胞病毒感染。
目的:巨细胞病毒(CMV)对炎症性肠病(IBD)的影响仍然是一个有争议的问题。本研究旨在从诊断和治疗方面评估CMV感染的IBD加重患者,并探讨CMV DNA水平在结肠炎发展中的重要性。材料和方法:回顾性扫描2016年1月至2021年12月在某大学医院接受IBD随访并有CMV结肠炎临床怀疑的患者。该研究包括所有接受结肠镜活检并初步诊断为巨细胞病毒性结肠炎的患者,并将组织病理学检测出结肠炎的患者与未发现结肠炎的患者进行比较。结果:39例IBD患者纳入研究。两组的人口学数据、临床表现和结果没有统计学上的显著差异。CMV结肠炎患者血清CMV DNA水平中位数为104拷贝/mL,低于无结肠炎患者(1216拷贝/mL) (p=0.008)。在巨细胞病毒结肠炎患者中,16例(61.5%)巨细胞病毒DNA水平为阴性或低。结论:在IBD患者中,巨细胞病毒结肠炎可能并不总是伴有巨细胞病毒血症。因此,阴性或低血清CMV DNA水平不足以排除CMV结肠炎。如临床高度怀疑,应计划进一步检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信