Intraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant Klebsiella pneumoniae: A Case Report.
{"title":"Intraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant <i>Klebsiella pneumoniae</i>: A Case Report.","authors":"Tuğba Yanık-Yalçın, Fatma İrem Yeşiler, Helin Şahintürk, Salih Gülşen, Özlem Kurt-Azap, Pınar Zeyneloğlu","doi":"10.36519/idcm.2024.384","DOIUrl":null,"url":null,"abstract":"<p><p>Ventriculoperitoneal shunts (VPSs) have been proven to be life-saving procedures, but their complications pose challenges, particularly in this era of rising antibiotic resistance. We report a critically ill case with VPS infection due to colistin-resistant <i>Klebsiella pneumoniae</i> that was treated with intraventricular tigecycline as salvage therapy without adverse events, resulting in microbiologic cure and clinical response. The use of intraventricular tigecycline in the treatment of colistin-resistant <i>K. pneumoniae</i> appears promising; however, appropriate dosage adjustments and evidence-based recommendations are needed.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"6 4","pages":"328-333"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687230/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases & clinical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36519/idcm.2024.384","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Ventriculoperitoneal shunts (VPSs) have been proven to be life-saving procedures, but their complications pose challenges, particularly in this era of rising antibiotic resistance. We report a critically ill case with VPS infection due to colistin-resistant Klebsiella pneumoniae that was treated with intraventricular tigecycline as salvage therapy without adverse events, resulting in microbiologic cure and clinical response. The use of intraventricular tigecycline in the treatment of colistin-resistant K. pneumoniae appears promising; however, appropriate dosage adjustments and evidence-based recommendations are needed.