Intraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant Klebsiella pneumoniae: A Case Report.

Infectious diseases & clinical microbiology Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI:10.36519/idcm.2024.384
Tuğba Yanık-Yalçın, Fatma İrem Yeşiler, Helin Şahintürk, Salih Gülşen, Özlem Kurt-Azap, Pınar Zeyneloğlu
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引用次数: 0

Abstract

Ventriculoperitoneal shunts (VPSs) have been proven to be life-saving procedures, but their complications pose challenges, particularly in this era of rising antibiotic resistance. We report a critically ill case with VPS infection due to colistin-resistant Klebsiella pneumoniae that was treated with intraventricular tigecycline as salvage therapy without adverse events, resulting in microbiologic cure and clinical response. The use of intraventricular tigecycline in the treatment of colistin-resistant K. pneumoniae appears promising; however, appropriate dosage adjustments and evidence-based recommendations are needed.

静脉注射替加环素治疗耐科里斯汀肺炎克雷伯氏菌引起的脑室腹腔分流脓毒性休克:病例报告。
脑室-腹膜分流术(vps)已被证明是挽救生命的手术,但其并发症带来了挑战,特别是在这个抗生素耐药性不断上升的时代。我们报告了一例因耐粘菌素肺炎克雷伯菌引起的VPS感染的危重病例,该病例采用脑室内替加环素作为挽救治疗,无不良事件,导致微生物学治愈和临床反应。使用脑室内替加环素治疗耐粘菌素肺炎克雷伯菌似乎很有希望;然而,需要适当的剂量调整和基于证据的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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