Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Yu-Jin Zhu, Yan Zhang, Yao Rao, Yong Jiang, Yong-Gang Liu, Jian-Zhou Li, Jia-Qi Yuan, Ying Zhao, Wen-Wen Zheng, Lin Ma, Chun-Yan Wang, Jia Li
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引用次数: 0

Abstract

Background: Autoimmune phenomena can be used in some patients with nonalcoholic fatty liver disease (NAFLD) in the clinic, but these patients are not autoimmune hepatitis patients.

Aim: To determine whether autoimmunity is present in patients with NAFLD, this study was performed.

Methods: A total of 104 patients with NAFLD diagnosed by liver biopsy at Tianjin Second People's Hospital between 2019 and 2023 were enrolled. The patients were divided into three groups according to their biopsy results: The NAFL (n = 36), nonalcoholic steatohepatitis (n = 51), and liver cirrhosis groups (n = 17).

Results: The differences in IgA, an immune marker, among the three groups of patients were statistically significant (P = 0.025). In all NAFLD patients, antinuclear antibody and anti-smooth muscle antibody were the most common autoantibodies. The antinuclear antibody detection rate was the highest at 48.1%. The cirrhosis group had the highest autoantibody positivity rate (64.7%). Portal enlargement is also common in NAFLD patients. The rates of positivity for portal lymphoplasmacytic infiltration, small bile duct hyperplasia and interfacial hepatitis were highest in the cirrhosis group; the differences between the cirrhosis group and the other two groups were significant (P < 0.05). Hepatocellular rosettes were identified only in the cirrhosis group (11.8%).

Conclusion: Autoimmune phenomena occur in NAFLD patients, especially in patients with NAFLD-related cirrhosis, in whom this phenomenon may be more pronounced.

基于肝脏病理对非酒精性脂肪肝患者自身免疫现象的评价
背景:自身免疫现象在临床上可用于部分非酒精性脂肪性肝病(NAFLD)患者,但这些患者并非自身免疫性肝炎患者。目的:本研究旨在确定NAFLD患者是否存在自身免疫。方法:选取2019 - 2023年天津市第二人民医院经肝活检确诊的NAFLD患者104例。根据活检结果将患者分为三组:NAFL组(n = 36)、非酒精性脂肪性肝炎组(n = 51)和肝硬化组(n = 17)。结果:三组患者免疫标志物IgA差异有统计学意义(P = 0.025)。在所有NAFLD患者中,抗核抗体和抗平滑肌抗体是最常见的自身抗体。抗核抗体检出率最高,为48.1%。肝硬化组自身抗体阳性率最高(64.7%)。门脉扩大在NAFLD患者中也很常见。肝硬化组门静脉淋巴浆细胞浸润、小胆管增生、界面肝炎阳性率最高;肝硬化组与其他两组比较差异有统计学意义(P < 0.05)。肝细胞玫瑰花结仅在肝硬化组中发现(11.8%)。结论:自身免疫现象在NAFLD患者中存在,特别是在NAFLD相关肝硬化患者中,这种现象可能更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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