Prognostic Value of Serum Neutrophil Gelatinase-Associated Lipocalin in Acute Heart Failure: A Meta-Analysis.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2024-11-29 eCollection Date: 2024-12-01 DOI:10.31083/j.rcm2512428

Zhendong Cheng, Xiaoxin Lin, Chaoxiang Xu, Zhilong Zhang, Naping Lin, Kefeng Cai

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引用次数: 0

Abstract

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is not only a sensitive marker of acute kidney injury but may also be a prognostic marker of acute heart failure (AHF). This study aimed to investigate the relationship between serum NGAL and all-cause death (ACD) and the composite outcome of ACD or AHF readmissions in patients with AHF.

Methods: The Embase, Cochrane Library, and PubMed databases were searched for articles focusing on serum NGAL and ACD and the composite outcome of ACD or AHF readmissions in patients with AHF. The hazard ratios (HRs) were pooled with random-effects models.

Results: The results from 2428 patients from seven studies were pooled in this article. Higher NGAL was relevant to an increased risk of ACD (HR, 1.89; 95% CI, 1.38 to 2.61) and the composite outcome of ACD or AHF readmissions (HR, 2.92; 95% CI, 1.62 to 5.27) in patients with AHF.

Conclusions: Serum NGAL has prognostic value for ACD and the composite outcome of ACD or AHF readmissions in AHF.

The prospero registration: CRD42022322057, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322057.

查看原文本刊更多论文

血清中性粒细胞明胶酶相关脂钙素在急性心力衰竭中的预后价值：一项荟萃分析。

背景：中性粒细胞明胶酶相关脂钙蛋白（NGAL）不仅是急性肾损伤的敏感标志物，而且可能是急性心力衰竭（AHF）的预后标志物。本研究旨在探讨血清NGAL与AHF患者全因死亡（ACD）以及ACD或AHF再入院的综合结局之间的关系。方法：检索Embase、Cochrane Library和PubMed数据库，检索有关血清NGAL和ACD以及AHF患者再入院ACD或AHF复合结局的文章。风险比（hr）与随机效应模型合并。结果：本文汇总了来自7项研究的2428例患者的结果。较高的NGAL与ACD风险增加相关(HR, 1.89；95% CI, 1.38 - 2.61)和ACD或AHF再入院的综合结局(HR, 2.92；AHF患者的95% CI， 1.62 - 5.27)。结论：血清NGAL对ACD及AHF中ACD或AHF再入院的综合预后具有预测价值。普洛斯彼罗注册：CRD42022322057， https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322057。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.