Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019

IF 4.8 2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Neoplasia Pub Date : 2025-02-01 DOI:10.1016/j.neo.2024.101114

Zhen Junhai , Meng Yang , Tan Zongbiao , Yan Wenxuan , Li Tiange , Wu Yanrui , Liu Chuan , Dong Weiguo

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引用次数: 0

Abstract

Aims

Very early-onset colorectal cancer (EOCRC) was defined as CRC diagnosed before the age of 35 proposed by the latest EOCRC management guideline. Until now, the disease burden of very EOCRC has never been reported. This study aimed to explore the burden of very EOCRC across the past three decades.

Methods

We extracted the data from Global Burden of Disease Study to analyze the disease burden of very EOCRC. Risk factors for the burden of deaths and disability-adjusted life years (DALYs) due to very EOCRC were also explored in this study. Additionally, decomposition analysis and frontier analysis were also conducted.

Results

Despite regional and gender variations, the global very EOCRC incidence cases increased from 21,874 (95 % UI: 20,386-23,470) to 41,545 (95 % UI: 37,978-45,523). Besides, the deaths cases also increased from 11,445 (95 % UI: 10,545-12,374) to 15,486 (95 % UI: 14,289-16,803), and the DALYs cases increased from 718,136 (95 % UI: 659,858-778,283) to 961,460 (95 % UI: 886,807-1,042,734). Decomposition analysis revealed the epidemiological change contributed most to the incidence burden of very EOCRC. Countries or regions with Sociodemographic Index (SDI) between 0.4 and 0.8 had greater disease burden improvement potential through frontier analysis. Diet low in milk, diet low in calcium, alcohol use, and high body-mass index were the main contributors to deaths and DALYs.

Conclusions

The increase in CRC burden among populations younger than 35 years globally requires vigilance from policy makers, physicians, and young individuals themselves, especially those regions experiencing faster growth burden of very EOCRC.

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1990 - 2019年极早发性结直肠癌的全球、区域和国家负担及其危险因素：2019年全球疾病负担研究的系统分析

目的：非常早发性结直肠癌（Very early-onset colorectal cancer， EOCRC）被最新的EOCRC管理指南定义为35岁之前诊断的结直肠癌。到目前为止，很少有EOCRC的疾病负担报告。本研究旨在探讨过去三十年中每个EOCRC的负担。方法：我们从全球疾病负担研究中提取数据，分析每个EOCRC的疾病负担。本研究还探讨了由于非常EOCRC导致的死亡负担和残疾调整生命年（DALYs）的风险因素。此外，还进行了分解分析和前沿分析。结果：尽管存在地区和性别差异，全球非常EOCRC发病率从21,874例（95% UI: 20,384 -23,470）增加到41,545例（95% UI: 37,978-45,523）。此外，死亡病例也从11,445例（95%死亡率：10,545-12,374）增加到15,486例（95%死亡率：14,289-16,803），残疾残疾者病例从718,136例（95%死亡率：659,858-778,283）增加到961,460例（95%死亡率：886,807-1,042,734）。分解分析表明，流行病学变化对所有EOCRC的发病负担贡献最大。前沿分析表明，社会人口指数（SDI）在0.4 ~ 0.8之间的国家或地区疾病负担改善潜力较大。低牛奶饮食、低钙饮食、饮酒和高体重指数是导致死亡和伤残调整生命年的主要因素。结论：全球35岁以下人群结直肠癌负担的增加需要政策制定者、医生和年轻人自身的警惕，特别是那些非常严重的结直肠癌负担增长更快的地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neoplasia 医学-肿瘤学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

26 days

期刊介绍： Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.