{"title":"Parental consanguinity and family history in relation to psoriasis and the role of sex: a case-control study.","authors":"Alanood N AlKhas, Ali H Ziyab","doi":"10.1159/000543351","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is caused by an interplay between intrinsic and extrinsic factors. Parental consanguinity increases homozygosity in the genome of the offspring, which in turn increases disease risk. The association between parental consanguinity and psoriasis in the offspring remains unexplored. Therefore, this study sought to evaluate the association of parental consanguinity and family history with psoriasis in the offspring, and to determine whether sex modulates the aforementioned associations.</p><p><strong>Methods: </strong>A case-control study enrolled adults aged 21 years and more. Psoriasis cases (n=139) diagnosed by dermatologists were enrolled from dermatology clinics. Controls (psoriasis-free subjects; n=278) were enrolled from workplaces. Study subjects reported information on parental consanguinity and family history of psoriasis. Logistic regression was applied to evaluate associations, and adjusted odds ratios (aOR) and 95% confidence intervals (CI) were estimated.</p><p><strong>Results: </strong>Cases compared to controls were more likely to report parental consanguinity (59.7% vs. 35.6%; p <0.001) and family history of psoriasis (56.8% vs. 23.7%; p <0.001). Both parental consanguinity (aOR: 2.13, 95% CI: 1.29-3.50) and family history of psoriasis (aOR: 3.43, 95% CI: 2.07-5.67) were associated with increased odds of having psoriasis. The observed association between parental consanguinity and psoriasis differed according to sex (Pinteraction = 0.008), with parental consanguinity being associated with psoriasis among males (aOR: 5.96, 95% CI: 2.39-14.82), but not among females (aOR: 1.36, 95% CI: 0.75-2.49).</p><p><strong>Conclusion: </strong>Psoriasis cases compared to controls were significantly more likely to report parental consanguinity and family history of psoriasis, with parental consanguinity being associated with psoriasis among males only.</p>","PeriodicalId":13226,"journal":{"name":"Human Heredity","volume":" ","pages":"1-18"},"PeriodicalIF":1.1000,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Heredity","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1159/000543351","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Psoriasis is caused by an interplay between intrinsic and extrinsic factors. Parental consanguinity increases homozygosity in the genome of the offspring, which in turn increases disease risk. The association between parental consanguinity and psoriasis in the offspring remains unexplored. Therefore, this study sought to evaluate the association of parental consanguinity and family history with psoriasis in the offspring, and to determine whether sex modulates the aforementioned associations.
Methods: A case-control study enrolled adults aged 21 years and more. Psoriasis cases (n=139) diagnosed by dermatologists were enrolled from dermatology clinics. Controls (psoriasis-free subjects; n=278) were enrolled from workplaces. Study subjects reported information on parental consanguinity and family history of psoriasis. Logistic regression was applied to evaluate associations, and adjusted odds ratios (aOR) and 95% confidence intervals (CI) were estimated.
Results: Cases compared to controls were more likely to report parental consanguinity (59.7% vs. 35.6%; p <0.001) and family history of psoriasis (56.8% vs. 23.7%; p <0.001). Both parental consanguinity (aOR: 2.13, 95% CI: 1.29-3.50) and family history of psoriasis (aOR: 3.43, 95% CI: 2.07-5.67) were associated with increased odds of having psoriasis. The observed association between parental consanguinity and psoriasis differed according to sex (Pinteraction = 0.008), with parental consanguinity being associated with psoriasis among males (aOR: 5.96, 95% CI: 2.39-14.82), but not among females (aOR: 1.36, 95% CI: 0.75-2.49).
Conclusion: Psoriasis cases compared to controls were significantly more likely to report parental consanguinity and family history of psoriasis, with parental consanguinity being associated with psoriasis among males only.
期刊介绍:
Gathering original research reports and short communications from all over the world, ''Human Heredity'' is devoted to methodological and applied research on the genetics of human populations, association and linkage analysis, genetic mechanisms of disease, and new methods for statistical genetics, for example, analysis of rare variants and results from next generation sequencing. The value of this information to many branches of medicine is shown by the number of citations the journal receives in fields ranging from immunology and hematology to epidemiology and public health planning, and the fact that at least 50% of all ''Human Heredity'' papers are still cited more than 8 years after publication (according to ISI Journal Citation Reports). Special issues on methodological topics (such as ‘Consanguinity and Genomics’ in 2014; ‘Analyzing Rare Variants in Complex Diseases’ in 2012) or reviews of advances in particular fields (‘Genetic Diversity in European Populations: Evolutionary Evidence and Medical Implications’ in 2014; ‘Genes and the Environment in Obesity’ in 2013) are published every year. Renowned experts in the field are invited to contribute to these special issues.