Preliminary study of the role of inner ear proteins in vestibular neuritis

IF 1.4 Q2 OTORHINOLARYNGOLOGY

Journal of Otology Pub Date : 2024-07-01 DOI:10.1016/j.joto.2024.04.003

Rong Wang , Weiwei Han , Li Li , Lulu Li , Xiaoxia Liu , Yunqin Wu , Weinv Fan

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引用次数: 0

Abstract

Objective

To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.

Methods

In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared.

Results

The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV.

Conclusions

Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.

查看原文本刊更多论文

内耳蛋白在前庭神经炎中的作用初步研究。

目的：评价前庭神经炎（VN）患者血浆中耳锥蛋白otoconin-90和otolin-1的水平，并确定将这些蛋白作为VN生物标志物的可行性。方法：在本初步研究中，我们招募了30例诊断为VN的患者和70名健康者，并对他们进行随访，以确定他们在随后的一段时间内是否有良性阵发性体位性眩晕（BPPV）。记录的数据包括身高、体重、糖尿病或高血压史。此外，测量并比较血浆耳托素-90和耳托素-1的水平。结果：耳托素-90和耳托素-1的血浆浓度在VN患者与健康对照组之间，继发于VN的BPPV患者与无BPPV的VN患者之间可能无显著差异。结论：血浆otolin- 90和otolin-1水平可能不能作为急性VN发作的生物标志物或预测继发于VN的BPPV的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Otology Medicine-Otorhinolaryngology

CiteScore

2.70

自引率

0.00%

发文量

461

审稿时长

18 days

期刊介绍： Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.