Clinical Proteomics Reveals Vulnerabilities in Noninvasive Breast Ductal Carcinoma and Drives Personalized Treatment Strategies.

IF 2 Q3 ONCOLOGY
Georgia Mitsa, Livia Florianova, Josiane Lafleur, Adriana Aguilar-Mahecha, Rene P Zahedi, Sonia V Del Rincon, Mark Basik, Christoph H Borchers, Gerald Batist
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引用次数: 0

Abstract

Significance: This study provides real-world evidence for DCIS, a disease for which currently no molecular tools or biomarkers exist, and gives an unbiased, comprehensive, and deep proteomic profile, identifying >380 actionable targets.

临床蛋白质组学揭示了非侵袭性乳腺导管癌的脆弱性,并推动了个性化的治疗策略。
导管原位癌(DCIS)是女性中最常见的非侵袭性乳腺病变类型(80%)。缺乏有效的预后标志物、有限的患者数量和可变的组织质量对诊断、风险分层、患者入组和临床研究结果有重大影响。在这里,我们对50例临床福尔马林固定石蜡包埋活检进行了无标记定量蛋白质组学,验证了来自独立遗传研究的22个假定的生物标志物。我们的综合蛋白质组学表型分析揭示了380多种差异表达蛋白和代谢脆弱性,可以为DCIS和浸润性导管癌(IDC)提供新的治疗策略。由于蛋白质和代谢酶或代谢抑制剂的易药物性质,该研究是临床研究和制药行业的高度兴趣。为了进一步评估我们的发现,并促进我们研究的临床转化,我们开发了一种高度多重靶向的蛋白质组学分析,用于90种与癌症代谢、RNA调节和标志性癌症途径相关的蛋白质,如PI3K/AKT/mTOR和EGFR/RAS/RAF。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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