Burkholderia cenocepacia outbreak linked to taps in a neonatal intensive care unit

IF 2.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Infection Disease & Health Pub Date : 2025-02-01 DOI:10.1016/j.idh.2024.08.001

R. Purcell , S. Ryan , J. Meyer , K. Cisera , N.L. Sherry , A. Stewart , A. Rindt , T.M. Korman , R.L. Stuart

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引用次数: 0

Abstract

Background

Burkholderia cenocepacia complex is an important cause of hospital acquired infections. We describe the management of an outbreak in a neonatal intensive care unit (NICU) due to tap colonisation.

Methods

Microbiological testing of touch (n = 26) and non-touch taps (n = 28), sinks and drains, including genomic sequencing of selected isolates. Thermal shocking of taps with 30 min of water flush at 60 °C. Tap aerators were changed with each thermal shock. Adjuvant disinfecting measures were applied to aerator mesh at the water exit point of the tap, point-of-use water filters, drains and sinks using hospital grade chlorine-based detergent.

Results

Across the 2 year outbreak, seven microbiological cultures of tap outlets were positive for B. cenocepacia. Two neonates had positive stool samples, and one neonate with gastroschisis had a bloodstream infection. Phylogenetic analysis determined the clinical and tap cultures positive for B. cenocepacia were genomically closely related. Monthly thermal shocking with adjunct disinfection measures and tap aerator changes was effective in controlling tap colonisation with longer intervals associated with positive tap B. cenocepacia cultures.

Conclusions

B. cenocepacia is an important cause of hospital-acquired infection in neonates. Plumbing and tap design is an important component to consider in the build of new NICUs.

查看原文本刊更多论文

与新生儿重症监护病房水龙头有关的结核杆菌爆发。

背景：结核杆菌复合体是医院获得性感染的重要原因。我们描述了在新生儿重症监护病房（NICU）暴发的管理，由于水龙头定植。方法：对26个接触式和28个非接触式水龙头、水槽和排水管进行微生物学检测，并对筛选出的分离菌株进行基因组测序。在60°C条件下，用水冲洗30分钟后对水龙头进行热冲击。每次热冲击时都要更换水龙头曝气器。使用医院级含氯洗涤剂对水龙头出水点的曝气网、使用点的水过滤器、排水管和水槽采取辅助消毒措施。结果：在2年的暴发中，有7个自来水口微生物培养呈青绿杆菌阳性。两名新生儿粪便样本呈阳性，一名胃裂新生儿血液感染。系统发育分析表明，临床培养物和结核分枝杆菌培养物在基因组上密切相关。每月进行热休克，辅以消毒措施和更换水龙头曝气设备，可有效控制水龙头定植，间隔时间越长，水龙头中青绿芽孢杆菌培养阳性。结论：新生儿结核杆菌是新生儿医院获得性感染的重要原因。管道和水龙头的设计是一个重要的组成部分，要考虑在新的新生儿重症监护病房的建设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection Disease & Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

5.70

自引率

5.70%

发文量

审稿时长

20 days

期刊介绍： The journal aims to be a platform for the publication and dissemination of knowledge in the area of infection and disease causing infection in humans. The journal is quarterly and publishes research, reviews, concise communications, commentary and other articles concerned with infection and disease affecting the health of an individual, organisation or population. The original and important articles in the journal investigate, report or discuss infection prevention and control; clinical, social, epidemiological or public health aspects of infectious disease; policy and planning for the control of infections; zoonoses; and vaccination related to disease in human health. Infection, Disease & Health provides a platform for the publication and dissemination of original knowledge at the nexus of the areas infection, Disease and health in a One Health context. One Health recognizes that the health of people is connected to the health of animals and the environment. One Health encourages and advances the collaborative efforts of multiple disciplines-working locally, nationally, and globally-to achieve the best health for people, animals, and our environment. This approach is fundamental because 6 out of every 10 infectious diseases in humans are zoonotic, or spread from animals. We would be expected to report or discuss infection prevention and control; clinical, social, epidemiological or public health aspects of infectious disease; policy and planning for the control of infections; zoonosis; and vaccination related to disease in human health. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in this ever-changing field. The audience of the journal includes researchers, clinicians, health workers and public policy professionals concerned with infection, disease and health.