{"title":"Valid overall odds ratio estimators using different stratified sampling schemes.","authors":"Hani M Samawi, Jing Kersey","doi":"10.1080/10543406.2024.2444232","DOIUrl":null,"url":null,"abstract":"<p><p>The study presents valid estimators for determining the overall odds ratio between two independent groups within stratified populations, utilizing both simple stratified sampling (SSRS) and stratified ranked set sampling (SRSS) methodologies. Through analytical derivations, we establish the expected values and variances for these estimators. Two distinct types of estimators namely, the naive weighted and the Cochran Mantel-Haenszel-Haenszel approaches are thoroughly examined. Our investigation encompasses an in-depth analysis of the expectation and variance of these estimators, shedding light on their performance characteristics. Through intensive simulation experiments, we discern that estimators based on SRSS exhibit notable advantages over their SSRS counterparts. To validate the efficacy of our proposed estimators, we conduct an empirical assessment utilizing data from the (2009-2010) National Health and Nutrition Examination Survey (NHANES). Through this analysis, we glean insights into the performance of the estimators in a real-world context. In summary, our study contributes valuable insights into the estimation of the overall odds ratio within stratified populations. By comparing SSRS and SRSS methodologies and evaluating different estimation approaches, we provide researchers with robust tools for analyzing odds ratios in diverse settings. Moreover, our empirical validation using NHANES data underscores the practical utility of the proposed estimators in real-world applications.</p>","PeriodicalId":54870,"journal":{"name":"Journal of Biopharmaceutical Statistics","volume":" ","pages":"1-20"},"PeriodicalIF":1.2000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biopharmaceutical Statistics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10543406.2024.2444232","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
The study presents valid estimators for determining the overall odds ratio between two independent groups within stratified populations, utilizing both simple stratified sampling (SSRS) and stratified ranked set sampling (SRSS) methodologies. Through analytical derivations, we establish the expected values and variances for these estimators. Two distinct types of estimators namely, the naive weighted and the Cochran Mantel-Haenszel-Haenszel approaches are thoroughly examined. Our investigation encompasses an in-depth analysis of the expectation and variance of these estimators, shedding light on their performance characteristics. Through intensive simulation experiments, we discern that estimators based on SRSS exhibit notable advantages over their SSRS counterparts. To validate the efficacy of our proposed estimators, we conduct an empirical assessment utilizing data from the (2009-2010) National Health and Nutrition Examination Survey (NHANES). Through this analysis, we glean insights into the performance of the estimators in a real-world context. In summary, our study contributes valuable insights into the estimation of the overall odds ratio within stratified populations. By comparing SSRS and SRSS methodologies and evaluating different estimation approaches, we provide researchers with robust tools for analyzing odds ratios in diverse settings. Moreover, our empirical validation using NHANES data underscores the practical utility of the proposed estimators in real-world applications.
期刊介绍:
The Journal of Biopharmaceutical Statistics, a rapid publication journal, discusses quality applications of statistics in biopharmaceutical research and development. Now publishing six times per year, it includes expositions of statistical methodology with immediate applicability to biopharmaceutical research in the form of full-length and short manuscripts, review articles, selected/invited conference papers, short articles, and letters to the editor. Addressing timely and provocative topics important to the biostatistical profession, the journal covers:
Drug, device, and biological research and development;
Drug screening and drug design;
Assessment of pharmacological activity;
Pharmaceutical formulation and scale-up;
Preclinical safety assessment;
Bioavailability, bioequivalence, and pharmacokinetics;
Phase, I, II, and III clinical development including complex innovative designs;
Premarket approval assessment of clinical safety;
Postmarketing surveillance;
Big data and artificial intelligence and applications.