Valid overall odds ratio estimators using different stratified sampling schemes.

IF 1.2 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Hani M Samawi, Jing Kersey
{"title":"Valid overall odds ratio estimators using different stratified sampling schemes.","authors":"Hani M Samawi, Jing Kersey","doi":"10.1080/10543406.2024.2444232","DOIUrl":null,"url":null,"abstract":"<p><p>The study presents valid estimators for determining the overall odds ratio between two independent groups within stratified populations, utilizing both simple stratified sampling (SSRS) and stratified ranked set sampling (SRSS) methodologies. Through analytical derivations, we establish the expected values and variances for these estimators. Two distinct types of estimators namely, the naive weighted and the Cochran Mantel-Haenszel-Haenszel approaches are thoroughly examined. Our investigation encompasses an in-depth analysis of the expectation and variance of these estimators, shedding light on their performance characteristics. Through intensive simulation experiments, we discern that estimators based on SRSS exhibit notable advantages over their SSRS counterparts. To validate the efficacy of our proposed estimators, we conduct an empirical assessment utilizing data from the (2009-2010) National Health and Nutrition Examination Survey (NHANES). Through this analysis, we glean insights into the performance of the estimators in a real-world context. In summary, our study contributes valuable insights into the estimation of the overall odds ratio within stratified populations. By comparing SSRS and SRSS methodologies and evaluating different estimation approaches, we provide researchers with robust tools for analyzing odds ratios in diverse settings. Moreover, our empirical validation using NHANES data underscores the practical utility of the proposed estimators in real-world applications.</p>","PeriodicalId":54870,"journal":{"name":"Journal of Biopharmaceutical Statistics","volume":" ","pages":"1-20"},"PeriodicalIF":1.2000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biopharmaceutical Statistics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10543406.2024.2444232","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

The study presents valid estimators for determining the overall odds ratio between two independent groups within stratified populations, utilizing both simple stratified sampling (SSRS) and stratified ranked set sampling (SRSS) methodologies. Through analytical derivations, we establish the expected values and variances for these estimators. Two distinct types of estimators namely, the naive weighted and the Cochran Mantel-Haenszel-Haenszel approaches are thoroughly examined. Our investigation encompasses an in-depth analysis of the expectation and variance of these estimators, shedding light on their performance characteristics. Through intensive simulation experiments, we discern that estimators based on SRSS exhibit notable advantages over their SSRS counterparts. To validate the efficacy of our proposed estimators, we conduct an empirical assessment utilizing data from the (2009-2010) National Health and Nutrition Examination Survey (NHANES). Through this analysis, we glean insights into the performance of the estimators in a real-world context. In summary, our study contributes valuable insights into the estimation of the overall odds ratio within stratified populations. By comparing SSRS and SRSS methodologies and evaluating different estimation approaches, we provide researchers with robust tools for analyzing odds ratios in diverse settings. Moreover, our empirical validation using NHANES data underscores the practical utility of the proposed estimators in real-world applications.

使用不同分层抽样方案的有效总体优势比估计。
本研究利用简单分层抽样(SSRS)和分层排名集抽样(SRSS)方法,提出了确定分层人群中两个独立群体之间总体优势比的有效估计。通过解析推导,我们建立了这些估计量的期望值和方差。两种不同类型的估计量,即朴素加权和Cochran Mantel-Haenszel-Haenszel方法进行了彻底的研究。我们的调查包含了对这些估计器的期望和方差的深入分析,揭示了它们的性能特征。通过密集的模拟实验,我们发现基于SRSS的估计器比基于SSRS的估计器具有显著的优势。为了验证我们提出的估计器的有效性,我们利用(2009-2010)国家健康与营养检查调查(NHANES)的数据进行了实证评估。通过此分析,我们收集了对真实环境中评估器性能的见解。总之,我们的研究为估计分层人群中的总体优势比提供了有价值的见解。通过比较SSRS和SRSS方法并评估不同的估计方法,我们为研究人员提供了在不同环境下分析优势比的强大工具。此外,我们使用NHANES数据的经验验证强调了所提出的估计器在实际应用中的实际效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Biopharmaceutical Statistics
Journal of Biopharmaceutical Statistics 医学-统计学与概率论
CiteScore
2.50
自引率
18.20%
发文量
71
审稿时长
6-12 weeks
期刊介绍: The Journal of Biopharmaceutical Statistics, a rapid publication journal, discusses quality applications of statistics in biopharmaceutical research and development. Now publishing six times per year, it includes expositions of statistical methodology with immediate applicability to biopharmaceutical research in the form of full-length and short manuscripts, review articles, selected/invited conference papers, short articles, and letters to the editor. Addressing timely and provocative topics important to the biostatistical profession, the journal covers: Drug, device, and biological research and development; Drug screening and drug design; Assessment of pharmacological activity; Pharmaceutical formulation and scale-up; Preclinical safety assessment; Bioavailability, bioequivalence, and pharmacokinetics; Phase, I, II, and III clinical development including complex innovative designs; Premarket approval assessment of clinical safety; Postmarketing surveillance; Big data and artificial intelligence and applications.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信