Hazard rates of recurrence for gastric cancer after curative resection: implications for postoperative surveillance.

IF 6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastric Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-26 DOI:10.1007/s10120-024-01576-5

Kyohei Kanematsu, Yuta Nakayama, Mie Tanabe, Junya Morita, Shinsuke Nagasawa, Takanobu Yamada, Takashi Ogata, Takashi Oshima

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引用次数: 0

Abstract

Background: Identifying the most effective postoperative surveillance interval in patients with gastric cancer (GC) remains challenging. To elucidate a logical and effective surveillance schedule, we analyzed GC recurrence risk trends after gastrectomy using the hazard function.

Methods: We retrospectively reviewed the medical records of 2503 patients who underwent curative GC resection between 2000 and 2018. We examined recurrence risk over time and the influence of clinicopathological variables on it.

Results: Overall, GC recurred in 291 patients (11.6%) over a median of 64.6 months. Recurrence risk was highest at approximately 11-months postoperatively (hazard rate [HR]: 0.0045), decreasing to half the peak at approximately 39-months postoperatively. Patients with Stage I GC maintained a low risk. In Stage II patients, the risk peaked at 16-months postoperatively (HR: 0.006) and gradually declined thereafter. Stage III patients had the highest risk at 11 months postoperatively (HR: 0.019), plateauing at 40 months.

Conclusions: We demonstrated significant cancer stage-dependent differences in postsurgical GC recurrence risk by using the hazard function. Reductions in surveillance intensity might be acceptable according to the individual risk of recurrence.

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胃癌根治性切除后复发的危险率：术后监测的意义。

背景：确定胃癌（GC）患者术后最有效的监测间隔仍然具有挑战性。为了阐明一个合理有效的监测计划，我们使用危害函数分析胃切除术后胃癌复发的风险趋势。方法：回顾性分析2000年至2018年2503例行根治性胃癌切除术患者的病历。我们检查了复发风险随着时间的推移和临床病理变量对它的影响。结果：总体而言，291例患者（11.6%）在中位64.6个月的时间内复发。术后约11个月复发风险最高（危险率[HR]: 0.0045），术后约39个月复发风险降至峰值的一半。I期胃癌患者维持低风险。在II期患者中，风险在术后16个月达到顶峰（HR: 0.006），此后逐渐下降。III期患者在术后11个月风险最高（HR: 0.019），在术后40个月达到稳定期。结论：我们通过使用危害函数证明了胃癌术后复发风险的显著分期差异。根据个体复发风险，降低监测强度是可以接受的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.