GPC-3 in hepatocellular carcinoma; A novel biomarker and molecular target

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Experimental cell research Pub Date : 2025-01-15 DOI:10.1016/j.yexcr.2024.114391

Hamed Azhdari Tehrani , Masood Zangi , Mobina Fathi , Kimia Vakili , Moustapha Hassan , Elham Rismani , Nikoo Hossein-Khannazer , Massoud Vosough

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引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) is a global health issue due to its late diagnosis and high recurrence rate. The early detection and diagnosis of HCC with specific and sensitive biomarkers and using novel treatment approaches to improve patient outcomes are essential. Glypican-3 (GPC-3) is a cell surface proteoglycan that is overexpressed in many tumors, including HCC. GPC-3 could be used as a specific biomarker for HCC early detection and could be a potential target for precise therapeutic strategies. Effective identification of GPC-3 could improve both diagnosis and targeted therapy of HCC. Moreover, targeted therapy using GPC-3 could result in a better treatment outcome. Recently, GPC3-targeted therapies have been used in different investigational therapeutic approaches like bi-specific/monoclonal antibodies, peptide vaccines, and CAR T cell therapies. This study aims to highlight the theranostic potential of GPC-3 as a novel biomarker for early detection and as a potential molecular target for HCC treatment as well.

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GPC-3在肝细胞癌中的表达；一种新的生物标志物和分子靶点。

肝细胞癌（HCC）因其诊断晚、复发率高而成为一个全球性的健康问题。HCC的早期检测和诊断具有特异性和敏感性的生物标志物，并使用新的治疗方法来改善患者的预后是至关重要的。Glypican-3 （GPC-3）是一种细胞表面蛋白聚糖，在包括HCC在内的许多肿瘤中过表达。GPC-3可以作为HCC早期检测的特异性生物标志物，并可能成为精确治疗策略的潜在靶点。GPC-3的有效鉴定有助于肝癌的诊断和靶向治疗。此外，使用GPC-3进行靶向治疗可能会产生更好的治疗效果。最近，gpc3靶向治疗已被用于不同的研究性治疗方法，如双特异性/单克隆抗体、肽疫苗和CAR - T细胞治疗。本研究旨在强调GPC-3作为早期检测的新型生物标志物和HCC治疗的潜在分子靶点的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental cell research 医学-细胞生物学

CiteScore

7.20

自引率

0.00%

发文量

295

审稿时长

30 days

期刊介绍： Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.