The Role of Podocytes in Lupus Pathology.

IF 5.7 2区医学 Q1 RHEUMATOLOGY

Current Rheumatology Reports Pub Date : 2024-12-28 DOI:10.1007/s11926-024-01175-4

Kayaho Maeda, Reza Abdi, George C Tsokos

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引用次数: 0

Abstract

Purpose of review: Kidney injury due to lupus nephritis (LN) is a severe and sometimes life-threatening sequela of systemic lupus erythematosus. Autoimmune injury to podocytes has been increasingly demonstrated to be a key driver of LN-related kidney injury because these cells play key roles in glomerular filtration barrier homeostasis. Irreparable podocyte injury impairs these processes and can lead to proteinuria, which is an indicator of poor prognosis in LN. This review highlights recent advances in our understanding of the involvement of podocytes in the pathogenesis of LN and discusses new podocyte-targeted therapeutic strategies.

Recent findings: Podocytes play a key role in glomerular filtration barrier homeostasis, both by helping to secrete and organize the glomerular basement membrane and by the formation of a glomerular slit diaphragm between adjacent cells. Recent studies revealed the involvement of abnormal calcium signaling, dysregulation of actin-related proteins, and mitotic catastrophe in LN progression. In addition, podocytes express many molecules related to the innate and adaptive immune responses. IgG from patients with LN induces direct injury of podocytes, inflammasome, and interactions with immune cells which have been shown to promote the development of LN. Our understanding of the role of podocytes in the pathogenesis of LN has been improved. Recent studies have shed light on potential therapeutic strategies targeting podocytes to control kidney injury.

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足细胞在狼疮病理中的作用。

综述目的：狼疮性肾炎（LN）引起的肾损伤是系统性红斑狼疮的严重且有时危及生命的后遗症。由于足细胞在肾小球滤过屏障稳态中起关键作用，自身免疫损伤对足细胞的影响越来越多地被证明是ln相关肾损伤的关键驱动因素。不可修复的足细胞损伤会损害这些过程，并可导致蛋白尿，这是LN预后不良的一个指标。本文综述了足细胞参与LN发病机制的最新进展，并讨论了新的足细胞靶向治疗策略。近期研究发现：足细胞在肾小球滤过屏障稳态中发挥关键作用，通过帮助分泌和组织肾小球基底膜以及在相邻细胞之间形成肾小球狭缝隔膜。最近的研究表明，异常钙信号，肌动蛋白相关蛋白的失调和有丝分裂突变参与LN的进展。此外，足细胞表达许多与先天和适应性免疫反应相关的分子。来自LN患者的IgG诱导足细胞、炎性体的直接损伤，并与免疫细胞相互作用，已被证明可促进LN的发展。我们对足细胞在LN发病机制中的作用的理解已经有所提高。最近的研究揭示了针对足细胞控制肾损伤的潜在治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.