Nanoencapsulation of vitamin B2 using chitosan-modified poly(lactic-co-glycolic acid) nanoparticles: Synthesis, characterization, and in vitro studies on simulated gastrointestinal stability and delivery

IF 3.4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Food Science Pub Date : 2024-12-28 DOI:10.1111/1750-3841.17631

Siriratchakorn Sathiensathaporn, Anna Solé-Porta, Duangkamon Baowan, Dakrong Pissuwan, Patompon Wongtrakoongate, Anna Roig, Kanlaya Prapainop Katewongsa

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引用次数: 0

Abstract

Vitamin B₂, or riboflavin, is essential for maintaining healthy cellular metabolism and function. However, its light sensitivity, poor water solubility, and gastrointestinal barriers limit its storage, delivery, and absorption. Selecting suitable nanomaterials for encapsulating vitamin B₂ is crucial to overcoming these challenges. This study employed chitosan-coated poly(lactic-co-glycolic acid) nanoparticles (CS-PLGA NPs) as a novel delivery system to enhance the bioavailability of vitamin B₂ for food fortification and nutraceutical applications. The nanoparticles, with sizes below 200 nm, exhibited greater stability than PLGA NPs after freeze-drying and in simulated body fluids. Encapsulation improved the photostability of vitamin B₂ under ultraviolet light and prolonged its release in simulated body fluids compared to non-encapsulated vitamin B₂. Furthermore, CS-PLGA NPs demonstrated higher uptake in intestinal epithelial cells (Caco-2), indicating enhanced transport and potential for use in fortified food systems. These findings underscore the promise of CS-PLGA NPs for delivering vitamin B₂ in food, nutraceutical, and pharmaceutical applications.

Practical Application

The use of chitosan-coated PLGA NPs for encapsulating vitamin B₂ offers a promising solution to enhance its bioavailability, especially for individuals with gastrointestinal absorption issues. This formulation improves stability, controlled release, and cellular uptake, which can lead to more effective supplementation strategies in nutraceutical and pharmaceutical applications. It could benefit patients with vitamin B₂ deficiencies, such as those with malabsorption disorders, by ensuring efficient delivery through the gastrointestinal tract. Additionally, this approach can be applied to other water-soluble vitamins or bioactive compounds, offering a versatile platform for improving the efficacy of oral supplements.

Abstract Image

查看原文本刊更多论文

壳聚糖修饰聚乳酸-羟基乙酸纳米颗粒纳米胶囊化维生素B2：合成、表征及体外模拟胃肠稳定性和给药研究

维生素B2或核黄素对维持健康的细胞代谢和功能至关重要。然而，它的光敏性、水溶性差和胃肠道屏障限制了它的储存、输送和吸收。选择合适的纳米材料来封装维生素B2是克服这些挑战的关键。本研究采用壳聚糖包被聚（乳酸-羟基乙酸）纳米颗粒（CS-PLGA NPs）作为一种新的递送系统，以提高维生素B2的生物利用度，用于食品强化和营养保健应用。尺寸小于200 nm的纳米颗粒在冷冻干燥和模拟体液中表现出比PLGA NPs更高的稳定性。与未包封的维生素B2相比，包封提高了维生素B2在紫外光下的光稳定性，延长了其在模拟体液中的释放时间。此外，CS-PLGA NPs在肠上皮细胞（Caco-2）中有更高的摄取，表明其转运能力增强，在强化食品系统中具有应用潜力。这些发现强调了CS-PLGA NPs在食品、营养食品和制药应用中输送维生素B2的前景。实际应用：使用壳聚糖包被的PLGA NPs包封维生素B2提供了一个很有前途的解决方案，以提高其生物利用度，特别是对有胃肠道吸收问题的个体。该配方提高了稳定性，控释和细胞摄取，这可以在营养保健和制药应用中导致更有效的补充策略。它可以通过确保通过胃肠道的有效输送，使维生素B2缺乏症患者受益，例如那些吸收不良的患者。此外，这种方法可以应用于其他水溶性维生素或生物活性化合物，为提高口服补充剂的功效提供了一个通用的平台。

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来源期刊

Journal of Food Science 工程技术-食品科技

CiteScore

7.10

自引率

2.60%

发文量

412

审稿时长

3.1 months

期刊介绍： The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science. The range of topics covered in the journal include: -Concise Reviews and Hypotheses in Food Science -New Horizons in Food Research -Integrated Food Science -Food Chemistry -Food Engineering, Materials Science, and Nanotechnology -Food Microbiology and Safety -Sensory and Consumer Sciences -Health, Nutrition, and Food -Toxicology and Chemical Food Safety The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.