Smoking and diabetic nephropathy: An updated systematic review and meta-analysis.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-12-27 DOI:10.1111/jdi.14385

Haihui Zhu, Liang Li, Songchun Liu, Jing Li

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引用次数: 0

Abstract

Objectives: Several studies have reported the potential association between smoking and diabetic nephropathy. However, the studies of non-significant association results were against the association between smoking and diabetic nephropathy. Therefore, the relationship between smoking and diabetic nephropathy was still debated and controversial.

Methods: Prospective cohort studies were included in the current meta-analysis. The tobacco smoking (current smokers or former smokers) and non-smoking groups in the enrolled studies were compared for the hazard ratio (HR) of diabetic nephropathy. Fifteen studies with 221,821 subjects were included in this meta-analysis. Subgroup analysis of the type 1 diabetes and type 2 diabetes groups was also performed individually to investigate the effects of different types of diabetes on the relationship between smoking and diabetic nephropathy.

Results: Current smoking was significantly associated with a greater log HR of diabetic nephropathy [1.44 (1.22-1.70), Z = 4.39]. In addition, former smoking was significantly associated with diabetic nephropathy [log HR = 1.04 (1.03-1.05), Z = 8.02]. The individual subgroup analysis of type 1 diabetes and type 2 diabetes subjects showed that smoking might be both significantly associated with greater log HRs of diabetic nephropathy.

Discussion: Current and former smoking might be the risk factors for diabetic nephropathy in the current meta-analytic results. The phenomenon of such significant associations were discovered in type 1 and 2 diabetes.

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吸烟与糖尿病肾病：一项最新的系统综述和荟萃分析。

目的：几项研究报道了吸烟与糖尿病肾病之间的潜在联系。然而，非显著相关的研究结果表明吸烟与糖尿病肾病之间没有相关性。因此，吸烟与糖尿病肾病的关系仍然存在争议和争议。方法：前瞻性队列研究纳入当前的荟萃分析。在纳入的研究中，吸烟组（当前吸烟者或曾经吸烟者）和不吸烟组比较糖尿病肾病的危险比（HR）。本荟萃分析纳入了15项研究，共221,821名受试者。对1型糖尿病和2型糖尿病组分别进行亚组分析，探讨不同类型糖尿病对吸烟与糖尿病肾病关系的影响。结果：吸烟与糖尿病肾病的log HR升高有显著相关性[1.44 (1.22-1.70),Z = 4.39]。此外，既往吸烟与糖尿病肾病有显著相关性[log HR = 1.04 (1.03-1.05), Z = 8.02]。1型糖尿病和2型糖尿病患者的个体亚组分析显示，吸烟可能与糖尿病肾病的log hr均显著相关。讨论：当前和既往吸烟可能是糖尿病肾病的危险因素。这种显著的关联现象在1型和2型糖尿病中被发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).