Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co-pathology

IF 4.4 2区 医学 Q1 CLINICAL NEUROLOGY
Francisco Hernández-Fernández, Isabel Martínez-Fernández, Rosa Barbella-Aponte, Inmaculada Feria Vilar, Oscar Ayo-Martín, Jorge García-García, Rosa Collado, Alberto Andrés, Mar Hernández-Guillamón, Francisco José Pena Pardo, Cristina Barrena, Miguel de la Fuente, Gemma Serrano-Heras, María Melero, Elena Lozano Setién, Luis López, Tomás Segura
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Abstract

Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta-amyloid peptide (Aβ), has a prion-like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3–4 decades. MRI was compatible with CAA, and Aβ deposition was confirmed. The third patient, who had a ventriculoperitoneal valve, also showed Aβ deposition in the peritoneum and diagnostic biomarkers of Alzheimer's disease. Co-pathology with Alzheimer disease and its iatrogenic transmission should be considered.

Abstract Image

医源性脑淀粉样血管病与阿尔茨海默病的共同病理。
医源性脑淀粉样血管病是一种因接触被β -淀粉样肽(a β)污染的神经外科材料或人类生长激素而引起的疾病,具有类似朊病毒的传播机制。我们报告了三名年龄在55岁以下的患者,他们接受了颅脑手术。他们都在30 - 40年后出现多发性脑出血、短暂性局灶性神经功能缺损和/或认知障碍。MRI与CAA相符,证实Aβ沉积。第三例患者患有脑室腹膜瓣膜,腹膜中也有a β沉积和阿尔茨海默病的诊断生物标志物。应考虑与阿尔茨海默病的共病理及其医源性传播。
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来源期刊
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)
CiteScore
9.10
自引率
1.90%
发文量
218
审稿时长
8 weeks
期刊介绍: Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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