Biosynthesis and In Vitro Cytotoxic Performance of Bimetallic ZnO/CeO2 Nanoparticles

IF 1.5 4区物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY

Brazilian Journal of Physics Pub Date : 2024-12-28 DOI:10.1007/s13538-024-01685-7

Khadijeh Hamidian, Mina Sarani

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引用次数: 0

Abstract

Our research explored an environmentally friendly approach for the synthesis of bimetallic zinc oxide-cerium oxide nanoparticles (ZC NP) through the utilization of Salvadora persica extract. We characterized the physicochemical properties of the synthesized nanoparticles using PXRD, Raman spectroscopy, FESEM, and EDX analyses. As a result, both main peaks of zinc oxide and cerium oxide NP appeared in the PXRD graph, which indicated the formation of bimetallic NP. Spherical morphology showed in the FESEM image which particles have a size of about 30–40 nm. The analysis of hemocompatibility indicated that the NP does not appreciably affect the integrity of erythrocytes at concentrations nearing 2000 µg mL⁻¹. The toxicity function of synthesized sample on human colon cancer (HT-29) and fibroblast (NIH/3T3) cells was considered through the results of MTT trial. The outcomes of synthesized NP displayed significant cytotoxic effects against HT-29 cells at 20.73 μg mL⁻¹ concentration as its IC50, while it was non-toxic on NIH-3T3 cells. Therefore, we suggest the applicability of our product in therapeutic applications such as drug delivery as well as industrial implementations.

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双金属ZnO/CeO2纳米颗粒的生物合成及体外细胞毒性能研究

本研究探索了一种利用木耳提取物合成双金属氧化锌-氧化铈纳米粒子（ZC NP）的环保方法。我们使用PXRD，拉曼光谱，FESEM和EDX分析表征了合成纳米颗粒的物理化学性质。结果表明，PXRD图中同时出现氧化锌和氧化铈的NP主峰，表明双金属NP的形成。FESEM图像显示为球形，颗粒尺寸约为30-40 nm。血液相容性分析表明，NP在浓度接近2000µg mL−1时不会明显影响红细胞的完整性。通过MTT试验的结果考虑合成样品对人结肠癌细胞（HT-29）和成纤维细胞（NIH/3T3）的毒性作用。合成的NP在20.73 μ mL−1浓度下对HT-29细胞具有显著的细胞毒作用，而对NIH-3T3细胞无毒性。因此，我们建议我们的产品适用于治疗应用，如药物输送和工业实施。

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来源期刊

Brazilian Journal of Physics 物理-物理：综合

CiteScore

2.50

自引率

6.20%

发文量

189

审稿时长

6.0 months

期刊介绍： The Brazilian Journal of Physics is a peer-reviewed international journal published by the Brazilian Physical Society (SBF). The journal publishes new and original research results from all areas of physics, obtained in Brazil and from anywhere else in the world. Contents include theoretical, practical and experimental papers as well as high-quality review papers. Submissions should follow the generally accepted structure for journal articles with basic elements: title, abstract, introduction, results, conclusions, and references.