Angeles Rovirosa, Faegheh Noorian, Sofia Cordoba, Francesc León, Valentina Lancellotta, Luca Tagliaferri, Antonio Herrreros
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引用次数: 0
Abstract
Purpose: Currently, there are many schedules for exclusive vaginal cuff brachytherapy (VCB). In 3D treatment planning for VCB dosimetry, parameters have not been analyzed. The aim of this study was to compare the most common schedules using dose-volume histogram metrics.
Material and methods: Three different computed tomography (CT) studies for vaginal cylinders of 3.5 cm, 3 cm, and 2.5 cm were performed. Clinical target volume (CTV) was delineated for 3 cm and 4 cm of vaginal length. Twelve schedules were analyzed obtaining overall vaginal surface dose (Gy) (EQD2 α/β = 10 and α/β = 3), overall D90 CTV (α/β = 10) (Gy), and overall D2cc (α/β = 3) for organs at risk (OARs), such as vagina, rectum, sigmoid, rectum, and bladder. Prescription at 5 mm from the applicator surface and at the surface were analyzed for each case.
Results: The overall vaginal surface dose and dose to CTV varied widely among the different schedules, and CTV delineation was necessary in case of surface prescription. The applicator diameter of 3.5 cm showed the best dosimetry results for vaginal surface dose. The overall D2cc OARs' doses changed in the different CT studies.
Conclusions: This dosimetry study allows for better selection of fractionation schedules, and helps to unify treatments among centers. Prospective studies are needed to establish the best schedule and CTV length in each patient using clinical data, such as late toxicity and relapses.
期刊介绍:
The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.