Is Pregnancy a Risk Factor for Progression of Diabetic Retinopathy and Nephropathy in Type 1 Diabetes? A Matched Cohort Study.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2024-12-24 DOI:10.1055/a-2489-4588

Francis Mimouni, Jane C Khoury, Shelley Ehrlich, Galit Sheffer-Mimouni, Barak Rosenn, Menachem Miodovnik

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引用次数: 0

Abstract

Objective: This study aimed to test the hypothesis that the development or deterioration of nephropathy and retinopathy over time is not affected by pregnancy in women with pregestational type 1 diabetes mellitus (T1DM).

Study design: Prospective, observational study of nephropathy and retinopathy follow-up during pregnancy and in a subsequent period of 2 years in a group of pregnant women with T1DM (study group) that we compared with pair-matched non-pregnant women with T1DM (control group) who underwent similar intensive follow-up.

Results: The rate of renal microvascular complications was similar at entry, 17.4% (4/23) in the study group and 21.7% (5/23) in the control group. At the last visit, both groups had nephropathy rates of 17.4% (4/23) and paired p-value of 1.00. Similarly, the rate of retinal microvascular complications of any grade was similar in both groups and remained so at the last follow-up examination.

Conclusion: Pregnancy per se does not appear to increase the risk for the development of, or the acceleration of the progression of retinopathy and nephropathy during a follow-up of at least 2 years in relatively healthy T1DM patients. This information is important for counseling young women with T1DM who are considering becoming pregnant.

Key points: · Retinopathy and nephropathy are major complications of T1DM.. · Pregnancy per se does not appear to cause major microvascular complications in T1DM.. · Pregnancy per se does not appear to aggravate retinopathy in T1DM..

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研究目的本研究旨在验证一个假设，即妊娠前 1 型糖尿病（T1DM）妇女的肾病和视网膜病变的发展或恶化不受妊娠的影响：研究设计：前瞻性观察研究，对一组 T1DM 孕妇（研究组）进行孕期及随后两年的肾病和视网膜病变随访，并与接受类似强化随访的配对非孕妇 T1DM 患者（对照组）进行比较：研究组和对照组的肾微血管并发症发生率相似，研究组为 17.4%（4/23），对照组为 21.7%（5/23）。在最后一次就诊时，两组的肾病发生率均为 17.4%（4/23），配对 p 值均为 1.00。同样，两组中任何级别的视网膜微血管并发症的发生率相似，在最后一次随访检查时也是如此：结论：在对相对健康的 T1DM 患者进行至少 2 年的随访期间，妊娠本身似乎并不会增加视网膜病变和肾病的发病风险或加速其进展。这一信息对于为考虑怀孕的 T1DM 年轻女性提供咨询非常重要：- 要点：视网膜病变和肾病是 T1DM 的主要并发症。- 妊娠本身似乎不会引起 T1DM 患者的主要微血管并发症。- 妊娠本身似乎不会加重T1DM患者的视网膜病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.