Burden of digestive congenital anomalies among children aged 0-14 years in 204 countries and territories, 1990-2021: results from the Global Burden of Disease Study 2021.

IF 2.4 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Xi Luo, Jie Luo, Jinhua Zhao, Jun Du, Deqin Lu, Huajian Gu
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引用次数: 0

Abstract

Objectives: We aim to delineate the digestive congenital abnormalities burden in children under 14 years old between 1990 and 2021.

Design: We implemented data from the Global Burden of Disease (GBD) 2021 database to evaluate digestive congenital abnormalities burden with different measures in 204 countries and territories from 1990 to 2021. We present precise estimations with 95% uncertainty intervals. In addition, we computed the estimated annual percentage change (EAPC) to examine the temporal patterns of these indicators.

Setting: It uses prevalence, deaths and disability-adjusted life years (DALYs) data from the GBD study to analyse this issue.

Participants: Patients with digestive congenital abnormalities diagnosis.

Outcomes: Total numbers, age-standardised rates (ASRs) of prevalence, mortality and DALYs and their EAPCs were the main outcomes among children aged 0-14 years.

Results: In 2021, 2206.79 thousand prevalent cases were reported worldwide, with digestive congenital anomalies accounting for 47.16 thousand deaths and 4324.56 thousand DALYs among children aged 0-14 years. Digestive congenital anomalies prevalence was mitigated by 8.15% between 1990 and 2021, with the global ASR of prevalence declining to 40.09 per 100 000. Digestive congenital anomalies mortality was mitigated by 35.35% between 1990 and 2021, with an ASR of deaths declining to 0.77 per 100 000. The worldwide burden of digestive congenital anomalies decreased by 34.96% in terms of DALYs from 1990 to 2021, with an ASR of 70.44 DALYs per 100 000 population. There was a significant hindrance in the prevalence, particularly among older children. The likelihood of digestive congenital abnormalities peaked during infancy (2-4 years) in all regions.

Conclusion: We highlight promising global declines in the digestive congenital anomalies burden among children over the past 32 years. Prevalence, deaths and DALYs associated with these anomalies have shown consistent decreases, although regional variations persist. These findings offer crucial insights for shaping effective prevention and management strategies for paediatric digestive congenital anomalies.

1990-2021年204个国家和地区0-14岁儿童消化系统先天性异常负担:《2021年全球疾病负担研究》结果
目的:我们旨在描述1990年至2021年间14岁以下儿童的消化先天性异常负担。设计:我们使用来自全球疾病负担(GBD) 2021数据库的数据,评估1990年至2021年204个国家和地区的消化先天性异常负担。我们给出了95%不确定区间的精确估计。此外,我们计算了估计的年百分比变化(EAPC)来检验这些指标的时间模式。背景:它使用GBD研究的患病率、死亡和残疾调整生命年(DALYs)数据来分析这一问题。研究对象:诊断为消化道先天性异常的患者。结局:0-14岁儿童的总人数、患病率、死亡率和残疾残疾率(DALYs)及其EAPCs是主要结局。结果:2021年,全球共报告2206.79万例流行病例,其中消化道先天性异常死亡47.16万例,0-14岁儿童DALYs 4324.56万例。1990年至2021年期间,消化系统先天性异常患病率降低了8.15%,全球患病率ASR降至每10万人40.09例。1990年至2021年期间,消化系统先天性异常死亡率降低了35.35%,死亡的ASR降至0.77 / 10万。从1990年到2021年,全球消化先天性异常负担的DALYs减少了34.96%,ASR为每10万人70.44 DALYs。在流行方面有很大的障碍,特别是在年龄较大的儿童中。在所有地区,先天性消化系统异常的可能性在婴儿期(2-4岁)达到高峰。结论:我们强调在过去的32年中,全球儿童消化系统先天性异常负担有希望下降。与这些异常有关的患病率、死亡率和伤残调整生命年均显示出持续下降,尽管区域差异仍然存在。这些发现为形成有效的预防和管理儿科消化先天性异常策略提供了重要的见解。
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来源期刊
BMJ Open
BMJ Open MEDICINE, GENERAL & INTERNAL-
CiteScore
4.40
自引率
3.40%
发文量
4510
审稿时长
2-3 weeks
期刊介绍: BMJ Open is an online, open access journal, dedicated to publishing medical research from all disciplines and therapeutic areas. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around fully open peer review and continuous publication, publishing research online as soon as the article is ready.
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