Association of patient- and hospital-level predictors with patterns of initial treatment in patients with rheumatoid arthritis: findings from a national cohort study.

IF 4.7 2区 医学 Q1 RHEUMATOLOGY
Zijing Yang, Edward Alveyn, Mark Russell, Katie Bechman, Callum Coalwood, Elizabeth Price, Abhishek Abhishek, Sam Norton, James Galloway
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引用次数: 0

Abstract

Objectives: To update the first-line conventional synthetic DMARDs (csDMARDs) prescribing pattern, describe change and variation across demographical and geographical factors in the RA population, and identify individual and hospital factors associated with it.

Methods: This retrospective cohort study included newly diagnosed RA adult patients from 1 May 2018 to 1 April 2023 in the UK. We used adjusted multinomial logistic regression with random effect to explore associations with different first-line csDMRAD prescription and to account for hospital-level clustering.

Results: We identified 15 462 RA patients who received csDMARD treatment. Overall, 57% received MTX monotherapy and 14% received MTX combination therapy as first-line treatment. MTX is the most frequently medication, following by HCQ and SSZ. Compared with non-MTX prescription, prescription of MTX monotherapy [adjusted odds ratio (aOR) 1.25 95% CI (1.22-1.29)] and MTX combination therapy [aOR 1.45 (1.38-1.52)] was significantly higher in patients with higher DAS28, but lower in the non-White individuals with comorbidities: lung disease, cancer, fracture and heart attack. Among those who received MTX, monotherapy is more likely be prescribed in patients with higher DAS28 [aOR 1.08 (1.05-1.11)] and without lung disease [aOR 0.5 (0.44-0.56)], compared with combination therapy. Around 20% of the variability in first-line csDMARD prescribing was attributed to the hospital level.

Conclusion: In this cohort study of new-onset RA population, both individual- and institution-level variation in first-line csDMARD treatment strategy was evident. Gender, ethnicity, disease activity, and comorbidities, especially lung disease, were associated with disparities at the individual level.

患者和医院水平的预测因素与类风湿关节炎患者初始治疗模式的关联:来自一项国家队列研究的结果
目的:更新一线常规合成疾病改善抗风湿药物(csDMARDs)处方模式,描述类风湿关节炎(RA)人群中人口和地理因素的变化和变异,并确定与之相关的个体和医院因素。方法:这项回顾性队列研究纳入了2018年5月1日至2023年4月1日在英国新诊断的RA成年患者。我们使用随机效应的调整多项逻辑回归来探索不同一线csDMRAD处方的关联,并解释医院水平的聚类。结果:我们确定了15 462例RA患者接受了csDMARD治疗。总体而言,57%的患者接受甲氨蝶呤(MTX)单药治疗,14%的患者接受甲氨蝶呤联合治疗作为一线治疗。MTX是最常见的药物,其次是羟氯喹和柳氮磺胺嘧啶。与非MTX处方相比,MTX单药处方(调整比值比aOR: 1.25 95%CI[1.22-1.29])和MTX联合治疗(调整比值比aOR: 1.45[1.38-1.52])在DAS28较高的患者中显著高于非白人患者(调整比值比aOR: 1.45[1.38-1.52]),而在有肺部疾病、癌症、骨折和心脏病等合并症的非白人患者中显著低于非MTX处方。在接受MTX治疗的患者中,与联合治疗相比,单药治疗更可能用于DAS28较高(aOR: 1.08[1.05-1.11])且无肺部疾病(aOR: 0.5[0.44-0.56])的患者。一线csDMARD处方中约20%的差异归因于医院水平。结论:在这项新发RA人群的队列研究中,csDMARD一线治疗策略的个体和机构水平差异都很明显。性别、种族、疾病活动度和合并症(尤其是肺病)与个体水平上的差异有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Rheumatology
Rheumatology 医学-风湿病学
CiteScore
9.40
自引率
7.30%
发文量
1091
审稿时长
2 months
期刊介绍: Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.
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