The Use of Single Pass Albumin Dialysis and Hemoadsorption in Management of Life-Threatening Amlodipine Overdose.

IF 1.4 4区 医学 Q3 UROLOGY & NEPHROLOGY
Wun Fung Hui, Ann Wing Man Choi, Wing Lum Cheung, Kam Lun Hon, Shu Wing Ku
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引用次数: 0

Abstract

We report the successful application of single pass albumin dialysis (SPAD) and hemoadsorption (HA) in two teenagers with amlodipine poisoning. A 16-year-old girl with amlodipine overdose developed refractory shock and lactic acidosis despite multiple inotropes, calcium, insulin, and glucagon infusion. SPAD was initiated 18 h after the incident for 21 h. She improved dramatically and was able to wean off all inotropes 54 h after admission. Another 16-year-old girl required extracorporeal membrane oxygenation (ECMO) support after deliberate consumption of 1100-mg amlodipine. SPAD was initiated 13 h after the incident for 38 h, followed by two more sessions of HA using the Cytosorb column. All inotropes were stopped 18 h after terminating the HA, and ECMO was weaned off 28 h later. There were no major complications during the therapy. Our cases demonstrated that early extracorporeal removal can be considered as an adjunctive therapy in children with life-threatening amlodipine overdose.

单次白蛋白透析和血液吸附在治疗危及生命的氨氯地平过量中的应用。
我们报告了单次白蛋白透析(SPAD)和血液吸附(HA)在两例氨氯地平中毒青少年中的成功应用。一名服用过量氨氯地平的16岁女孩,尽管注射了多种肌力药物、钙、胰岛素和胰高血糖素,但仍发生了难治性休克和乳酸性酸中毒。SPAD在事故发生后18小时启动,持续21小时。她的病情明显好转,并在入院后54小时能够戒断所有的肌力药物。另一名16岁女孩在故意服用1100毫克氨氯地平后需要体外膜氧合(ECMO)支持。事件发生后13小时开始SPAD,持续38小时,随后使用Cytosorb柱进行两次HA。HA终止后18 h停用所有肌力,28 h后停用ECMO。治疗期间无重大并发症发生。我们的病例表明,早期体外切除可以作为危及生命的过量氨氯地平儿童的辅助治疗。
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来源期刊
Seminars in Dialysis
Seminars in Dialysis 医学-泌尿学与肾脏学
CiteScore
3.00
自引率
6.20%
发文量
91
审稿时长
4-8 weeks
期刊介绍: Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.
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