Endosomal traffic disorders: a driving force behind neurodegenerative diseases.

IF 10.8 1区医学 Q1 NEUROSCIENCES

Translational Neurodegeneration Pub Date : 2024-12-24 DOI:10.1186/s40035-024-00460-7

Jianru Dong, Weiwei Tong, Mingyan Liu, Mengyu Liu, Jinyue Liu, Xin Jin, Ju Chen, Huachao Jia, Menglin Gao, Minjie Wei, Ying Duan, Xin Zhong

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引用次数: 0

Abstract

Endosomes are crucial sites for intracellular material sorting and transportation. Endosomal transport is a critical process involved in the selective uptake, processing, and intracellular transport of substances. The equilibrium between endocytosis and circulation mediated by the endosome-centered transport pathway plays a significant role in cell homeostasis, signal transduction, and immune response. In recent years, there have been hints linking endosomal transport abnormalities to neurodegenerative diseases, including Alzheimer's disease. Nonetheless, the related mechanisms remain unclear. Here, we provide an overview of endosomal-centered transport pathways and highlight potential physiological processes regulated by these pathways, with a particular focus on the correlation of endosomal trafficking disorders with common pathological features of neurodegenerative diseases. Additionally, we summarize potential therapeutic agents targeting endosomal trafficking for the treatment of neurodegenerative diseases.

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内体交通紊乱：神经退行性疾病背后的驱动力。

核内体是细胞内物质分选和运输的关键部位。内体转运是参与物质选择性摄取、加工和细胞内转运的关键过程。内吞作用与循环之间的平衡是由内核转运途径介导的，在细胞稳态、信号转导和免疫应答中起着重要作用。近年来，有迹象表明内体转运异常与神经退行性疾病，包括阿尔茨海默病有关。尽管如此，相关机制仍不清楚。在这里，我们概述了以内体为中心的转运途径，并强调了由这些途径调节的潜在生理过程，特别关注内体转运障碍与神经退行性疾病的常见病理特征的相关性。此外，我们总结了潜在的治疗药物靶向内体运输治疗神经退行性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Neurodegeneration Neuroscience-Cognitive Neuroscience

CiteScore

19.50

自引率

0.80%

发文量

审稿时长

10 weeks

期刊介绍： Translational Neurodegeneration, an open-access, peer-reviewed journal, addresses all aspects of neurodegenerative diseases. It serves as a prominent platform for research, therapeutics, and education, fostering discussions and insights across basic, translational, and clinical research domains. Covering Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions, it welcomes contributions on epidemiology, pathogenesis, diagnosis, prevention, drug development, rehabilitation, and drug delivery. Scientists, clinicians, and physician-scientists are encouraged to share their work in this specialized journal tailored to their fields.