Patient-Reported Outcomes of Visual Disturbances with a Trifocal Intraocular Lens: A Meta-Analysis.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-02-01 Epub Date: 2024-12-24 DOI:10.1007/s40123-024-01085-9

Dagny Zhu, Suyen Karki, Mukesh Dhariwal, Erkki Soini, Christian Asseburg

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引用次数: 0

Abstract

Introduction: Diffractive trifocal intraocular lenses (IOLs) provide good vision at distance, intermediate, and near, but can also cause positive dysphotopsias. This meta-analysis pooled published evidence on visual disturbances after bilateral implantation of the PanOptix (TFNTXX) IOL for patients undergoing cataract surgery.

Method: A systematic literature search was conducted in PubMed and congress presentations from April 2021 to December 2022 to identify studies with patient-reported outcomes on the incidence of visual disturbances (starbursts, halos, glare) post bilateral implantation of PanOptix IOL during cataract surgery. Random-effects meta-analysis was performed to generate pooled proportions for patient-reported visual disturbances with a 95% confidence interval [CI].

Results: Eleven unique studies were included, spanning 580 patients with bilateral implantation of PanOptix IOL from 10 countries with 1 to 12 months follow-up. In summary, 33.6% of patients with bilateral PanOptix implantation experienced glare, 43.9% experienced halos, and 30.4% experienced starbursts. Among these patients, small percentages reported severe glare (2.9%), severe halos (5.4%), and severe starbursts (3.4%). Only 0.8%, 1.4%, and 2.6% of patients found glare, halos, and starbursts, respectively, to be very bothersome.

Conclusion: Halos are the most frequently reported visual disturbances. However, the likelihood of experiencing severe and/or very bothersome visual disturbances (halos, glare, starbursts) is approximately 5% and 3%, respectively, after bilateral implantation of PanOptix IOL. These findings should inform clinical decision-making and treatment choices when selecting the most appropriate IOL implant for cataract surgery.

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三焦人工晶状体视力障碍患者报告的结果：一项荟萃分析。

衍射三焦人工晶状体（iol）在远距离、中距离和近处提供良好的视力，但也可能导致阳性的光失。这项荟萃分析汇集了已发表的关于白内障手术患者双侧植入PanOptix （TFNTXX）人工晶状体后视力障碍的证据。方法：从2021年4月至2022年12月，系统检索PubMed和会议报告中的文献，以确定患者报告的关于白内障手术中双侧植入PanOptix IOL后视力障碍（星状爆发、光晕、眩光）发生率的研究。进行随机效应荟萃分析，以95%可信区间（CI）生成患者报告的视觉障碍的合并比例。结果：纳入了11项独特的研究，包括来自10个国家的580例双侧PanOptix人工晶体植入术患者，随访1 ~ 12个月。综上所述，双侧PanOptix植入术患者中有33.6%出现眩光，43.9%出现光晕，30.4%出现星暴。在这些患者中，有一小部分报告严重眩光（2.9%），严重晕（5.4%）和严重星暴（3.4%）。分别只有0.8%、1.4%和2.6%的患者认为眩光、光晕和星暴非常令人讨厌。结论：光晕是最常见的视觉障碍。然而，在双侧植入PanOptix人工晶体后，出现严重和/或非常麻烦的视觉障碍（光晕、眩光、星爆）的可能性分别约为5%和3%。这些发现应该为临床决策和治疗选择提供参考，以便在白内障手术中选择最合适的人工晶状体。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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