Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review).

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

International journal of molecular medicine Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI:10.3892/ijmm.2024.5478

Simin Gu, Yiyuan Zheng, Chong Chen, Jing Liu, Yanping Wang, Junmin Wang, Yong Li

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引用次数: 0

Abstract

Bupleurum, a Traditional Chinese Medicine (TCM) herb, is widely used in China and other Asian countries to manage chronic liver inflammation and viral hepatitis. Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum, exhibits extensive pharmacological properties, including anti‑inflammatory, antioxidant, anti‑apoptotic, anti‑fibrotic and anti‑cancer effects, making it a therapeutic candidate for numerous diseases. Clarifying the targets and molecular mechanisms underlying TCM compounds is essential for scientifically validating TCM's therapeutic roles in disease prevention and treatment, as well as for identifying novel therapeutic targets and lead compounds. This analysis comprehensively examines SSD's mechanisms across various conditions, such as myocardial injury, pulmonary diseases, hepatic disorders, renal pathologies, neurological disorders, diabetes and cancer. In addition, challenges and potential solutions encountered in SSD research are addressed. SSD is posited as a promising monomer for multifaceted therapeutic applications and this article aims to enhance researchers' understanding of the current landscape of SSD studies, offering strategic insights to guide future investigations.

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柴草皂苷D在多种疾病中的分子机制研究进展（综述）。

柴胡是一种传统中药，在中国和其他亚洲国家被广泛用于治疗慢性肝脏炎症和病毒性肝炎。柴胡皂苷D （Saikosaponin D， SSD）是一种从柴胡中提取的三萜类皂苷，具有抗炎、抗氧化、抗凋亡、抗纤维化和抗癌等多种药理作用，是多种疾病的治疗候选药物。明确中药化合物的靶点和分子机制，对于科学验证中药在疾病防治中的治疗作用，以及寻找新的治疗靶点和先导化合物至关重要。该分析全面考察了SSD在各种情况下的机制，如心肌损伤、肺部疾病、肝脏疾病、肾脏病变、神经系统疾病、糖尿病和癌症。此外，还讨论了固态硬盘研究中遇到的挑战和可能的解决方案。SSD被认为是一种有前景的单体，可用于多方面的治疗应用，本文旨在提高研究人员对SSD研究现状的理解，为指导未来的研究提供战略见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of molecular medicine 医学-医学：研究与实验

CiteScore

12.30

自引率

0.00%

发文量

124

审稿时长

3 months

期刊介绍： The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.