Cobalt-catalyzed regioselective diazidation of 1‑aryl-1,3-dienes enabled by a single electron transfer/radical addition/group transfer relay process

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-24 DOI:10.1039/d4qo02180k

Chifan Zhu, Junju Mai, Xiao-Jing Li, Mingyuan Shi, Xiasen Dong, Huinan Fu, Mei-Hua Shen, Hua-Dong Xu

引用次数: 0

Abstract

A novel cobalt-catalyzed 1,2-diazidation of 1‑aryl-1,3-dienes by using TMSN3 as azide source has been reported. A series of vicinal diazides containing unsaturated bonds that are amenable to further functionalization were synthesised with excellent regioselectivity and stereoselectivity under mild conditions. Preliminary mechanistic studies suggest that the reaction proceeds via a single electron transfer/radical addition/group transfer relay process.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.