Thermodynamics and models for small nanoparticles upon protein adsorption

IF 2.9 3区 化学 Q3 CHEMISTRY, PHYSICAL
Miao-Miao Yin, Yi-Bo Yuan, Xin Ding, Yan-Jun Hu and Feng-Lei Jiang
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引用次数: 0

Abstract

Proteins are some of the most important components in living organisms. When nanoparticles enter a living system, they swiftly interact with proteins to produce the so-called “protein corona”, which depicts the adsorption of proteins on large nanoparticles (normally tens to hundreds of nanometers). However, the sizes of small nanoparticles (typically, fluorescent nanomaterials such as quantum dots, noble metal nanoclusters, carbon dots, etc.) are less than 10 nm, which are comparable or even much smaller than those of proteins. Can proteins also adsorb onto the surface of small nanoparticles to form a “protein corona”? In this perspective, the interactions between small nanoparticles with proteins are discussed in detail, including the main characterization methods and thermodynamic mechanisms. The interaction models are summarized. In particular, the concept of a “protein complex” is emphasized.

Abstract Image

Abstract Image

小纳米颗粒对蛋白质吸附的热力学和模型
蛋白质是生物体中最重要的组成部分。当纳米粒子进入一个生命系统时,它们迅速与蛋白质相互作用,产生所谓的“蛋白质冕”,这描述了蛋白质在大纳米粒子(通常是几十到几百纳米)上的吸附。而小型纳米颗粒(典型的荧光纳米材料如量子点、贵金属纳米团簇、碳点等)的尺寸小于10纳米,与蛋白质的尺寸相当甚至小得多。蛋白质也能吸附在小纳米颗粒表面形成“蛋白质冠”吗?在此基础上,详细讨论了纳米颗粒与蛋白质的相互作用,包括主要表征方法和热力学机制。总结了相互作用模型。特别强调了“蛋白质复合物”的概念。
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来源期刊
Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics 化学-物理:原子、分子和化学物理
CiteScore
5.50
自引率
9.10%
发文量
2675
审稿时长
2.0 months
期刊介绍: Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.
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