Extent of peritoneal metastases from colorectal cancer is not associated with changes in thrombin generation or fibrinolysis.

IF 1.4 Q4 ONCOLOGY

Pleura and Peritoneum Pub Date : 2024-11-06 eCollection Date: 2024-12-01 DOI:10.1515/pp-2024-0009

Mikkel Lundbech, Andreas Engel Krag, Lene Hjerrild Iversen, Birgitte Brandsborg, Anne-Mette Hvas

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Abstract

Objectives: Cancer cells can activate coagulation and inhibit fibrinolysis. The aim was to investigate the association between the burden of peritoneal metastases from colorectal cancer (PM-CRC) and biomarkers reflecting thrombin generation and fibrinolysis.

Methods: A cohort of 55 patients with PM-CRC scheduled for cytoreductive surgery. Patients were grouped by the peritoneal cancer index (PCI) assessed intraoperatively into limited PM-CRC (PCI≤15) and extensive PM-CRC (PCI>15). Blood samples were obtained before surgery. Thrombin generation was measured in vivo by thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2), and ex vivo by the endogenous thrombin potential (ETP). Fibrinolysis was analyzed with fibrin clot lysis assay, fibrinogen, and D-dimer.

Results: Non-significantly decreased thrombin generation by F1+2 (p=0.72), TAT (p=0.32), and ETP (p=0.19) were observed in patients with extensive PM-CRC (n=9) compared with limited PM-CRC (n=46). Non-significantly prolonged 50 % clot lysis time were found in patients with extensive PM-CRC than in patients with limited PM-CRC.

Conclusions: Minor non-significant differences in thrombin generation and fibrinolysis were found between patients with extensive PM-CRC and limited PM-CRC. Thus, increased peritoneal metastatic burden from colorectal cancer does not seem to affect thrombin generation and fibrinolysis.

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结直肠癌腹膜转移的范围与凝血酶生成或纤维蛋白溶解的变化无关。

目的：癌细胞具有激活凝血和抑制纤溶的作用。目的是研究结直肠癌腹膜转移负担（PM-CRC）与反映凝血酶生成和纤维蛋白溶解的生物标志物之间的关系。方法：55例计划行细胞减少手术的PM-CRC患者。根据术中评估的腹膜癌指数（PCI）将患者分为局限性PM-CRC （PCI≤15）和广泛性PM-CRC （PCI>15）。术前采集血液样本。体内通过凝血酶-抗凝血酶复合物（TAT）和凝血酶原片段1+2 （F1+2）测定凝血酶生成，体外通过内源性凝血酶电位（ETP）测定凝血酶生成。采用纤维蛋白凝块溶解试验、纤维蛋白原和d -二聚体分析纤维蛋白溶解。结果：广泛性PM-CRC患者（n=9）与局限性PM-CRC患者（n=46）相比，F1+2 （p=0.72）、TAT （p=0.32）和ETP （p=0.19）的凝血酶生成均未显著降低。广泛性PM-CRC患者的凝块溶解时间比局限性PM-CRC患者无显著延长50% %。结论：广泛性PM-CRC和局限性PM-CRC患者在凝血酶生成和纤溶方面存在轻微的无显著差异。因此，结直肠癌腹膜转移负担的增加似乎不影响凝血酶的产生和纤维蛋白溶解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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