The effect of cancer cell-derived exosomal proteins on macrophage polarization: An in-depth review

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Experimental cell research Pub Date : 2025-01-15 DOI:10.1016/j.yexcr.2024.114393

Khandu Wadhonkar , Soumalya Das , Ramachandran Subramanian , Mobbassar Hassan Sk , Yashi Singh , Mirza S. Baig

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Abstract

Cancer is characterized by unregulated cell proliferation, enabling it to invade and spread to different organs and tissues in the body. Cancer progression is intricately influenced by the complex dynamics within the tumor microenvironment (TME). The TME is a composite and dynamic network comprising cancer cells and various immune cells, including tumor-associated macrophages. Exosomes facilitate the communication between different cancer cells as well as other types of cells. This review particularly focuses on exosomal proteins derived from different cancer cells in mounting the complex crosstalk between cells of cancer and macrophages within the TME. Most cancer-derived exosomal proteins polarize macrophages towards M2 phenotype, promoting cancer aggressiveness, while a few have role switching towards the M1 phenotype, inhibiting cancer proliferation, respectively. In this review, we summarize, for the first time, the dual impact of cancer cell-derived exosomal proteins on macrophage polarization and the associated signaling pathways, offering valuable insights for developing innovative therapeutic strategies against diverse cancer types.

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癌细胞来源的外泌体蛋白对巨噬细胞极化的影响：深入综述。

背景：癌症的特点是不受调节的细胞增殖，使其能够侵入和扩散到身体的不同器官和组织。肿瘤的进展受到肿瘤微环境（TME）内复杂动力学的复杂影响。肿瘤微环境（tumor microenvironment， TME）是一个由癌细胞和包括肿瘤相关巨噬细胞在内的多种免疫细胞组成的复合动态网络。外泌体促进不同癌细胞以及其他类型细胞之间的交流。本综述特别关注来自不同癌细胞的外泌体蛋白在TME内癌细胞和巨噬细胞之间的复杂串扰。大多数癌症来源的外泌体蛋白将巨噬细胞极化为M2表型，促进癌症侵袭性，而少数蛋白则向M1表型转换，分别抑制癌症增殖。在这篇综述中，我们首次总结了癌细胞来源的外泌体蛋白对巨噬细胞极化和相关信号通路的双重影响，为开发针对不同癌症类型的创新治疗策略提供了有价值的见解。结论：来自不同癌细胞的外泌体蛋白参与了巨噬细胞向经典活化M1表型或交替活化M2表型的极化。这篇综述提供了见解，并描述了不同的癌细胞来源的外泌体蛋白和导致巨噬细胞极化并进一步促进或抑制癌症进展的相关信号通路的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental cell research 医学-细胞生物学

CiteScore

7.20

自引率

0.00%

发文量

295

审稿时长

30 days

期刊介绍： Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.