Photoinduced copper-catalyzed three-component alkylarylation of alkenes involving C-S bonds cleavage of sulfonium salts

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-23 DOI:10.1039/d4qo01740d

Hui Chen, Xuan Shang, Nan Jiang, Quan Zhou, Kewen Tang, Long-Jin Zhong, Yu Liu

引用次数: 0

Abstract

We report a novel visible light-induced copper catalyzed intermolecular 1,2-alkylarylation of alkenes with cyclic sulfonium salts and nucleophiles via the selective C-S bond cleavage for the construction of thioether-containing 1,1-diarylalkanes. In this transformation, the remote aryl thioether-containing aliphatic alkyl chains and nucleophiles are successively installed into the C=C bond of alkenes through radical relay coupling process in a single operation. Furthermore, the mild reaction conditions allow for good compatibility in the scope of styrenes, sulfonium salts and nucleophiles, as well as bioactive molecules and derivatives.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.