ALSUntangled #77: Psilocybin.

IF 2.8
Bhavya Bakshi, Sandeep Yerraguntla, Carmel Armon, Paul Barkhaus, Tulio Bertorini, Robert Bowser, Sarah Breevoort, Mark Bromberg, Andrew Brown, Gregory T Carter, Vincent Chang, Jesse Crayle, Timothy Fullam, Maxwell Greene, Terry Heiman-Patterson, Carlayne Jackson, Sartaj Jhooty, Elise Mallon, Javier Mascias Cadavid, Christopher J Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Yuyao Sun, Olivia Wang, Paul Wicks, Martina Wiedau, Richard Bedlack
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引用次数: 0

Abstract

ALSUntangled reviews alternate and off-label treatments prompted by patient interest. Here, we review psilocybin, a chemical derived from mushrooms and belonging in the category of drugs known as psychedelics. Psilocybin has plausible mechanisms for slowing ALS progression because of its ability to cross the blood brain barrier and effect neurogenesis and inflammation. Currently, there are no pre-clinical ALS models, case reports, or trials for psilocybin and ALS in the context of disease modifying therapy. Depending on dosing, there can be a high risk of psychological side effects including hallucinations and physical harm. Based on the above information, we do not currently support the use of psilocybin as a means to slow ALS progression.

77:裸盖菇素。
ALSUntangled回顾了由患者兴趣引起的替代治疗和标签外治疗。在这里,我们回顾裸盖菇素,一种从蘑菇中提取的化学物质,属于被称为迷幻药的药物类别。裸盖菇素具有减缓ALS进展的合理机制,因为它能够穿过血脑屏障并影响神经发生和炎症。目前,尚无关于裸盖菇素和ALS在疾病修饰治疗方面的临床前ALS模型、病例报告或试验。根据剂量的不同,可能会有很高的心理副作用,包括幻觉和身体伤害。基于上述信息,我们目前不支持使用裸盖菇素作为减缓ALS进展的手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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