Pituitary adenomas in children: surgical course and functional outcome. Lille cohort retrospective study

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY

Neurochirurgie Pub Date : 2025-01-01 DOI:10.1016/j.neuchi.2024.101625

Mélodie-Anne Karnoub , Matthieu Vinchon , Emilie Merlen , Gustavo Soto Ares , Richard Assaker

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引用次数: 0

Abstract

Context

Pituitary Neuroendocrine Tumors are rare in children, but challenging, implying the two purposes to cure the child, and preserve pituitary function. In this paper, we describe our population of children who underwent endoscopic endonasal resection of a pituitary adenoma, in Lille University Hospital.

Patients and methods

Between 2007 and 2021, all children undergoing EEN surgery for pituitary adenoma were included. Age at surgery, surgical course, type of adenoma, knosp grade and extent of resection were collected.

Results

26 patients were included. 88% were female. All adenomas were functioning. 15 patients had prolactine-secreting adenomas (58%), 9 patients had ACTH-secreting adenomas (35%) and 2 patients had GH-secreting adenomas (8%). Visual disturbance was present at diagnosis in 5 patients. Among them, visual function was improved after surgery in 4 patients and stable in one. Surgical course was always easy. 66% of prolactinomas, all Cushing disease were in remission after surgery. The two patients with acromegaly had to undergo complementary treatment. Follow up was maintained at least 5 years.

Discussion

Surgical treatment remain mainstay in pituitary adenomas. In the pediatric population, surgery can be performed safely and efficiently via en EEN approach.

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儿童垂体腺瘤：手术过程和功能结局。里尔队列回顾性研究。

背景：垂体神经内分泌肿瘤在儿童中罕见，但具有挑战性，这意味着治疗儿童和保持垂体功能的两个目的。在本文中，我们描述了我们的人口的儿童谁接受内镜鼻内切除垂体腺瘤，在里尔大学医院。患者和方法：2007年至2021年间，所有因垂体腺瘤接受EEN手术的儿童均纳入研究。收集手术年龄、手术过程、腺瘤类型、结节分级及切除程度。结果：纳入26例患者。88%是女性。所有腺瘤功能正常。泌乳素腺瘤15例（58%），促肾上腺皮质激素腺瘤9例（35%），gh腺瘤2例（8%）。5例患者诊断时存在视觉障碍。其中4例术后视力改善，1例术后视力稳定。手术过程总是很容易。66%的催乳素瘤，所有库欣病术后均缓解。这两名肢端肥大症患者必须接受补充治疗。随访至少5年。讨论：手术治疗仍是垂体腺瘤的主要治疗方法。在儿科人群中，通过en - EEN方法可以安全有效地进行手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochirurgie 医学-临床神经学

CiteScore

2.70

自引率

6.20%

发文量

100

审稿时长

29 days

期刊介绍： Neurochirurgie publishes articles on treatment, teaching and research, neurosurgery training and the professional aspects of our discipline, and also the history and progress of neurosurgery. It focuses on pathologies of the head, spine and central and peripheral nervous systems and their vascularization. All aspects of the specialty are dealt with: trauma, tumor, degenerative disease, infection, vascular pathology, and radiosurgery, and pediatrics. Transversal studies are also welcome: neuroanatomy, neurophysiology, neurology, neuropediatrics, psychiatry, neuropsychology, physical medicine and neurologic rehabilitation, neuro-anesthesia, neurologic intensive care, neuroradiology, functional exploration, neuropathology, neuro-ophthalmology, otoneurology, maxillofacial surgery, neuro-endocrinology and spine surgery. Technical and methodological aspects are also taken onboard: diagnostic and therapeutic techniques, methods for assessing results, epidemiology, surgical, interventional and radiological techniques, simulations and pathophysiological hypotheses, and educational tools. The editorial board may refuse submissions that fail to meet the journal''s aims and scope; such studies will not be peer-reviewed, and the editor in chief will promptly inform the corresponding author, so as not to delay submission to a more suitable journal. With a view to attracting an international audience of both readers and writers, Neurochirurgie especially welcomes articles in English, and gives priority to original studies. Other kinds of article - reviews, case reports, technical notes and meta-analyses - are equally published. Every year, a special edition is dedicated to the topic selected by the French Society of Neurosurgery for its annual report.