Gamma oscillations and auditory perception: A cluster-based statistic investigation in infants at higher likelihood of autism and developmental language disorder.

Abstract

The ability to process auditory information is one of the foundations of the ability to appropriately acquire language. Moreover, early difficulties in basic auditory abilities have cascading effects on the appropriate wiring of brain networks underlying higher-order linguistic processes. Language impairments represent core difficulties in two different but partially overlapping disorders: developmental language disorder (DLD) and autism spectrum disorder (ASD). The aim of this study was to investigate basic auditory processes in 12-month-old infants at high likelihood (HL) of developing either DLD or ASD in response to standard tones embedded in a non-speech multi-feature oddball paradigm to discern early differences in how auditory processing relates to language acquisition. To do so, we focused on gamma-band oscillations due to the role of gamma activity in coordinating activity among neural assemblies and thus enabling both sensory and higher-order processing. Considering reported hemispheric asymmetries in auditory and linguistic processing, we chose to refer to a cluster-based method to investigate the whole scalp activity in the gamma range. Our results show that HL-ASD infants are characterized by differences in auditory gamma compared with their typically developing peers. These results may imply an enhanced sensitivity to auditory stimuli in HL-ASD infants that might negatively affect their ability to regulate responses.