Efficacy of behavioral cough suppression therapy for refractory chronic cough or unexplained chronic cough: a meta-analysis of randomized controlled trials.

IF 3.3 3区医学 Q2 RESPIRATORY SYSTEM

Therapeutic Advances in Respiratory Disease Pub Date : 2024-01-01 DOI:10.1177/17534666241305952

Baiyi Yi, Shengyuan Wang, Xianghuai Xu, Li Yu

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引用次数: 0

Abstract

Background: The efficacy of behavioral cough suppression therapy (BCST) for refractory chronic cough (RCC) and unexplained chronic cough (UCC) remains unclear due to limited evidence from small-scale single-center studies.

Objective: To compile and assess the quality of evidence from randomized controlled trials to evaluate the effectiveness of BCST.

Design: This study included randomized controlled studies and self-controlled studies related to BCST involving adult patients with RCC or UCC.

Data sources and methods: We conducted an extensive search of various English and Chinese databases (e.g., PubMed, CNKI, CBM, VIP, and Wanfang Data Journal Full-text Database) and the Clinical Trial Registration website up to April 2024. The selected studies underwent meta-analysis to investigate the impact of BCST on the patient's quality of life and cough frequency.

Results: The included 12 studies showed that BCST significantly improved the Leicester Cough Questionnaire scores of the patients (MD = 4.50, 95% CI (4.03, 4.97), p < 0.001) compared to the simple verbal education group. In addition, a significant reduction in objective cough frequency was observed in patients compared to before BCST, with a statistically significant difference (MD = -8.06, 95% CI (-9.71, -6.41), p < 0.001). Other measures of cough symptoms, such as symptom scores, Visual Analog Scale (VAS) scores, and Cough Severity Index (CSI) also showed improvement.

Conclusion: This meta-analysis revealed positive therapeutic effects of BCST in patients with RCC/UCC, potentially advancing its application in broader clinical settings.

Trial registration: This study was registered on PROSPERO with the registration number CRD42024530746.

查看原文本刊更多论文

行为止咳疗法治疗难治性慢性咳嗽或不明原因慢性咳嗽的疗效：随机对照试验的荟萃分析。

背景：由于小规模单中心研究证据有限，行为止咳疗法（BCST）治疗难治性慢性咳嗽（RCC）和不明原因慢性咳嗽（UCC）的疗效尚不清楚。目的：收集和评价BCST有效性的随机对照试验证据质量。设计：本研究包括与BCST相关的随机对照研究和自我对照研究，涉及成年RCC或UCC患者。数据来源和方法：我们广泛检索了截至2024年4月的各种中英文数据库（如PubMed、CNKI、CBM、VIP、万方数据期刊全文数据库）和临床试验注册网站。选定的研究进行了荟萃分析，以调查BCST对患者生活质量和咳嗽频率的影响。结果：纳入的12项研究显示，BCST显著提高了患者的莱斯特咳嗽问卷评分(MD = 4.50, 95% CI (4.03, 4.97), p。结论：本荟萃分析显示BCST对RCC/UCC患者的积极治疗效果，有可能促进其在更广泛的临床应用。试验注册：本研究在PROSPERO上注册，注册号为CRD42024530746。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Respiratory Disease RESPIRATORY SYSTEM-

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Respiratory Disease delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of respiratory disease.