The many faces of DGAT1.

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-02-01 Epub Date: 2024-12-19 DOI:10.1016/j.lfs.2024.123322

Ewa Oleszycka, Kamila Kwiecień, Beata Grygier, Joanna Cichy, Patrycja Kwiecińska

引用次数: 0

Abstract

Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a multifaced enzyme with a wide spectrum of substrates, from lipids through waxes to retinoids, which makes it an interesting therapeutic target. DGAT1 inhibitors are currently at various stages of preclinical and clinical trials, mostly related to metabolic diseases. Interestingly, in recent years, a growing amount of research has shown the influence of DGAT1 on immune cell metabolism and functions, highlighting its important role during infections and tumorigenesis. In this review, we aim to elucidate the potential immunomodulatory effect of DGAT1 in physiological and pathological conditions.

查看原文本刊更多论文

DGAT1的许多面。

酰基辅酶a：二酰基甘油酰基转移酶1 （DGAT1）是一种多面酶，具有广泛的底物，从脂质到蜡质再到类维生素a，这使其成为一个有趣的治疗靶点。DGAT1抑制剂目前处于临床前和临床试验的各个阶段，主要与代谢性疾病有关。有趣的是，近年来越来越多的研究表明DGAT1对免疫细胞代谢和功能的影响，突出了其在感染和肿瘤发生中的重要作用。在这篇综述中，我们旨在阐明DGAT1在生理和病理条件下的潜在免疫调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.